Service
   

Preliminary Phase

  • Feasibility study.
  • Screening study to optimize pegylation conditions.
  • Pegylation product separation and purification.
  • Pegylation product characterization (method development for degree of pegylation, precise characterization of conjugation site, measurement of un-pegylated protein and free PEG, mass spectrometry of target products etc.).

Large-scale Study Phase

  • Optimize and scale-up of pegylation conditions, product separation and purification.
  • Product structural characterization (molecular weight determination, conjugation site and pegylation degree).
  • Scale-up production of hundreds of miligram to gram levels of target products.
  • Pegylation product characterization (method development for degree of pegylation, precise characterization of conjugation.
   

Drug Candidate Evaluation Phase

  • To measure biologics’ activity and to determine half-life extension.
  • The results may be subsequently used to guide and optimize the pegylation on PEG derivative selection, conjugation site and degree of pegylation.
  • Scale-up production of hundreds of miligram to gram levels of target products.
  • Pegylation product characterization (method development for degree of pegylation, precise characterization of conjugation.