1. Basic information

Name: M-PEG-CM, MPEG-CM, Methoxy-PEG-Carboxymethyl

Structural characteristics: mPEG-CM has PEG chain and carboxymethyl (COOH) group, and the two are connected by methylene (CH2) bond


2. Introduction of functional groups

The main functional group of mPEG-CM is carboxymethyl (COOH), which gives it the following unique chemical properties:

Esterification: The carboxyl group of mPEG-CM can be esterified with the hydroxyl group to form an ester bond. This reaction has been widely used in drug synthesis, material modification and other fields.

Affinity substitution reaction: Carboxylic groups can also undergo affinity substitution reactions with amino groups to form amide bonds. This reaction plays an important role in biological coupling and protein modification.


3. Application

Due to its unique functional and chemical properties, mPEG-CM has a wide range of applications in several fields:

Biomaterial modification: mPEG-CM can be used to improve the biocompatibility and functionality of biomaterial, reduce immunogenicity, and increase stability and persistence.

Polymer material modification: In the field of materials science, mPEG-CM can be used as a modifier to enhance the mechanical properties and thermal stability of materials, and prepare new composite materials with excellent properties.

Crosslinking agent or coupling agent: The good solubility and reactivity of mPEG-CM enable it to act as a crosslinking agent or coupling agent to promote the binding and composite between different materials.

Drug carrier: In the drug delivery system, mPEG-CM can be used as a drug carrier to bind drug molecules to PEG chains to form stable drug-PEG complexes, improve drug bioavailability, and reduce toxicity and side effects.

Product technical advantage

SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.

High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.

High quality PEG molecular weight control -PDI <1.05

The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.

Relevant recommendation

mPEG-NH2	3-arm PEG-OH
mPEG-CM	3-arm PEG-NH2
mPEG-SA	3-arm PEG-CM
mPEG-SH	3-arm PEG-SH
mPEG-pALD	3-arm PEG-SC
mPEG-MAL	3-arm PEG-N3
mPEG-SC	3-arm PEG-NH2·HCl
mPEG-NPC	4-arm PEG-OH
mPEG-SS	4-arm PEG-NH2
mPEG-N3	4-arm PEG-CM
mPEG-AA	4-arm PEG-SA
mPEG-MA	4-arm PEG-SH
mPEG-VS	6-arm PEG-OH
mPEG-NH2·HCl	6-arm PEG-NH2
2-arm PEG-OH	6-arm PEG-CM
2-arm PEG-COOH	6-arm PEG-SA
2-arm PEG-NHS	6-arm PEG-SH
2-arm PEG-MAL	8-arm PEG-NH2
2-arm PEG-NH2	8-arm PEG-CM
2-arm PEG-Acetal	8-arm PEG-SA
2-arm PEG-CHO	8-arm PEG-SH
2-arm PEG-N3	8-arm PEG-pALD