1. Basic information about mPEG-MAL
English name: mPEG-MAL, Methoxy PEG-Maleimide, mPEG-Maleimide, Methoxy PEG-Mal.
Chinese name: methoxy polyethylene glycol maleimide.
CAS number: 99126-64-4.
Appearance: Depending on molecular weight, usually white to yellowish solid, sometimes may appear as a viscous liquid.
Molecular weight: Can be customized according to requirements, common range between 0.4k and 10k.
Solubility: mPEG-MAL has a good solubility in water, but also soluble in most organic solvents, such as methanol, ethanol and dichloromethane.
Storage conditions: Should be dry, away from light storage, temperature does not exceed -20℃.
2. Molecular structure of mPEG-MAL
The molecular structure of mPEG-MAL consists of two parts: the polyethylene glycol (PEG) backbone and the Maleimide functional group.
Polyethylene glycol (PEG) backbone: The polyethylene glycol unit (CH2CH2O) is repeatedly connected, providing good hydrophilicity and biocompatibility. This gives mPEG-MAL a unique advantage in biomedical applications.
Maleimide functional group: Maleimide is an electrophilic functional group that can undergo nucleophilic addition reactions with molecules containing sulfhydryl groups (-SH) to form stable sulfur bonds. This reactivity allows mPEG-MAL to specifically bind to a variety of biomolecules (e.g. proteins, antibodies, peptides, etc.), giving them new functions or uses.
3. Application of maleimide functional groups
Maleimide functional groups play a crucial role in mPEG-MAL, and their applications are mainly reflected in the following aspects:
Chemical modification and biomolecular coupling: Using the reactivity of maleimide functional groups, mPEG-MAL can react with biomolecules containing sulfhydryl, amino, or hydroxyl functional groups to form stable amide or thioether bonds. This coupling technique is widely used in biomedical research for the preparation of biomaterials and drug delivery systems with specific functions.
Preparation of drug delivery vector: By coupling mPEG-MAL with drugs, drug delivery vectors with good water solubility and stability can be prepared. These vectors are able to deliver drugs to the target site more efficiently, improving treatment effectiveness and reducing side effects.
Preparation of biosensors: mPEG-MAL can also be used to modify the surface of biosensors to improve the sensitivity and selectivity of sensors by introducing PEG chains and maleimide functional groups.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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