English name: mPEG-NPC, mPEG-Nitrophenyl Carbonate
Chinese name: Methoxy-polyethylene glycol - nitrophenyl carbonate
Molecular weight: Depending on the length of the PEG chain, the molecular weight of mPEG-NPC has a variety of specifications, such as 1k, 2k, 3.4k, 5k, 10k, 20k, etc., and can be customized according to needs.
Appearance: Viscous liquid or solid powder, the specific form depends on the molecular weight.
2. Introduction of functional groups
The core functional group of mPEG-NPC is the nitrophenyl carbonate (NPC) group. This functional group gives mPEG-NPC its unique chemical properties and application value.
Nitrophenyl carbonate (NPC) groups:
Reactivity: NPC groups can react with amino (-NH2) groups under the right conditions to form stable amide bonds. This reactive property makes mPEG-NPC an important amino reactive PEG derivative.
pH sensitivity: NPC groups exhibit high reactivity in specific pH ranges (e.g. 6.5 to 9.5), which facilitates chemical modifications under mild conditions.
Application: Due to the reactivity of NPC groups, mPEG-NPC can be used to modify proteins, peptides, or any other surface with a usable amino group on the lysine residue or N-terminal. This modification can improve the stability and solubility of biomolecules or reduce their immunogenicity.
3. Application and use
mPEG-NPC has a wide range of applications in biomedicine, materials science and chemical synthesis.
Biomedical: mPEG-NPC can be used to prepare PEG-modified biomolecules, such as PEG-modified proteins, antibodies, etc. These modified biomolecules have better pharmacokinetic properties and lower immunogenicity, thus improving drug efficacy and safety.
Materials Science: mPEG-NPC can be used to prepare PEG-modified material surfaces to improve the biocompatibility and stain resistance of materials. This modified material has potential application value in biomedical implants, tissue engineering and other fields.
Chemical synthesis: The NPC groups of mPEG-NPC can react with molecules containing amino groups to form new chemical bonds. This reaction property provides a new way and method for chemical synthesis.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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