mPEG-PA, also known as Methoxypoly(ethylene glycol) Propionic Acid or methoxy-polyethylene glycol propionic acid, is an important PEG derivative.
Mpeg-pa is synthesized by a chemical reaction of polyethylene glycol monomethyl ether (mPEG) and propionic acid (PA). Among them, the mPEG part provides good hydrophilicity and molecular weight controllability, while the PA part introduces carboxyl functional groups, giving MPEG-PA unique chemical properties and functions.
2. Introduction of functional groups
The functional groups of mPEG-PA are mainly concentrated in the PA part, which is the carboxylic group (-COOH) on the propionic acid chain segment. This functional group has the following characteristics:
Reactivity: Carboxyl group is a highly reactive functional group, which can chemically react with other functional groups (such as amino, hydroxyl, etc.) to form ester bonds, amide bonds, etc. This reactivity allows mPEG-PA to be used to modify biomolecules (such as proteins, peptides, etc.), changing their physical and chemical properties and biological behavior.
Biocompatibility: mPEG-PA has good biocompatibility, which is mainly due to the introduction of PEG segments. PEG, as a kind of polymer compound, has the characteristics of good water solubility, biocompatibility and stability. As a result, mPEG-PA can exist stably in organisms and interact with biomolecules without causing significant immune responses or toxic reactions.
Drug delivery: The carboxyl functional group of mPEG-PA also enables it to be used as a component of drug delivery systems. Through its unique chemical structure and biocompatibility, mPEG-PA can achieve the targeted delivery and release of drugs, improve the therapeutic effect of drugs and reduce side effects.
3. Application field
Due to the functional properties of mPEG-PA, it has a wide range of applications in several fields:
Biomedical: mPEG-PA can be used in targeted drug development, tissue engineering, bioimaging and other fields. Its high drug loading capacity and good biocompatibility enable the drug to be released slowly in the body, extending the time of action of the drug and reducing adverse reactions.
Materials science: The hydrophilicity and molecular weight controllability of mPEG-PA make it an important raw material for the preparation of new materials. For example, it can be used for surface modification of nanomaterials to improve their stability and biocompatibility.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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