1. Structure and characteristics of mPEG-SA
The structure of mPEG-SA is characterized by the connection of a succinic acid group (i.e., succinic acid group) at one end of the PEG (polyethylene glycol) chain. The PEG chain gives mPEG-SA good hydrophilicity, biocompatibility and low immunogenicity, while the succinic acid group gives it specific chemical properties.
Succinic acid group (succinic acid group) :Chemical properties: The succinic acid group contains a carboxyl group (-COOH), which allows mPEG-SA to chemically react with other molecules (such as amino groups) through carboxyl groups, such as esterification or amidation.
Reactivity: The carboxyl group of succinic acid group has high reactivity, and can be coupled with molecules containing amino, hydroxyl and other functional groups, so as to achieve PEG chain coupling or modification.
Application: Due to the introduction of succinic acid group, mPEG-SA has a wide range of applications in biomedicine, chemical synthesis and other fields. For example, it can be used in the construction of targeted delivery systems to achieve the precise delivery and release of drugs through coupling with other biomolecules (e.g. antibodies, drugs, etc.).
3. Application field
Biomedicine:
It is used for PEG-modification of proteins, peptides and small molecule drugs to improve the stability, solubility and biocompatibility of drugs. Build a targeted delivery system to achieve accurate drug delivery and release.
Chemical synthesis:
As an important raw material for the synthesis of PEG-modified compounds, such as PEG-modified liposomes, polymer nanoparticles, etc. It is used to prepare PEG derivatives with specific functions, such as PEG-modified sensors, catalysts, etc.
Cosmetics:
As an emulsifier, stabilizer and penetration enhancer, it is used to improve the texture, stability and efficacy of cosmetics.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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