Mpeg-sc is composed of monomethoxypolyethylene glycol (mPEG) and succinimide carbonate (SC) connected by ester bond. Among them, the mPEG part provides good water solubility and biocompatibility, while the SC part acts as an active functional group, giving MPEG-SC unique chemical properties.
2. Introduction of functional group SC
a. Chemical structure:
The SC functional group, succinimide carbonic ester, has a specific chemical structure. It contains two carbonyl groups and one amide group, which have the ability to interact with different molecules.
b. Reactivity:
SC functional groups have high reactivity, especially under mild physiological conditions (such as pH in the range of 7 to 8.5).
It can react with molecules containing primary amino groups (-NH2) to form stable carbamate bonds. This reaction is highly specific and usually has a high reaction efficiency.
c. Application:
Due to the reactivity and specificity of SC functional groups, mPEG-SC has a wide range of applications in the biomedical field.
Drug delivery: mPEG-SC can be used as a component of the drug delivery system to connect with drug molecules or other biomolecules through SC functional groups to achieve targeted delivery and controlled release of drugs.
Biomolecular modification: Using the reactivity of SC functional groups, mPEG-SC can modify biomolecules (such as proteins, peptides, etc.) to improve their stability, solubility or biological activity.
Material surface modification: mPEG-SC can also be used for material surface modification, through the reaction of SC functional groups with amino groups on the surface of the material, the introduction of PEG chains, thereby improving the hydrophilicity and biocompatibility of the material.
3. Other properties of mPEG-SC
In addition to the properties of SC functional groups, mPEG-SC also has the following properties:
Water solubility and biocompatibility: Due to the presence of PEG chains, mPEG-SC has good water solubility and biocompatibility, which makes it stable in vivo and in vitro.
Chemical stability: mPEG-SC can be stored at room temperature for a long time without deterioration, which provides convenience for its application in the biomedical field.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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