1. Overview of mPEG-SG
Mpeg-sg combines the properties of methoxypolyethylene glycol (mPEG) and succinimide glutaric acid (SG). The mPEG component provides good water solubility and biocompatibility, which enables MPEG-SG to reduce the stimulation and immune response to biological tissues when used in organisms. The SG part introduces an active group that enables mPEG-SG to react with amino groups in biological macromolecules (such as proteins, peptides, etc.) to form stable amide bonds. This reaction mechanism makes mPEG-SG play a key role in biochemical coupling.
2. Introduction of functional groups
a. Chemical structure
SG, or succinimide glutaric acid, is present as an active functional group in mPEG-SG. Its chemical structure contains a succinimide ester group (also known as the NHS ester group), which is a key site for the reaction of the SG part with the amino group in the biological macromolecule.
b. Functional features
Active reaction: The NHS ester group in SG can react efficiently with the amino group in the biomacromolecule to form a stable amide bond. This reaction property enables mPEG-SG to be used for modification and labeling of proteins, peptides and other biomolecules.
Biocompatibility: Because the SG part has good compatibility with biological macromolecules, mPEG-SG can maintain its stability and activity when used in organisms without triggering obvious immune responses.
Enhanced stability: By reacting with biomolecules, mPEG-SG can introduce polyethylene glycol chains, thereby altering the stability of the biomolecules. This modification helps to enhance the solubility and stability of biomolecules, reduce the immunogenicity of peptides and proteins, and inhibit the non-specific binding of charged molecules on the modified surface.
c. Application field
Biomolecular modification and labeling: Using the active reaction properties of SG functional groups, mPEG-SG can be used to modify and label proteins, peptides and other biomolecules. This modification facilitates the study of the functions and interactions of biomolecules, as well as the preparation of biomaterials with specific functions.
Drug delivery systems: mPEG-SG can also be used to prepare drug delivery systems, such as targeted delivery and controlled release by coupling drug molecules. This delivery system helps improve the efficacy and safety of drugs.
Product technical advantage
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
