1. Basic information about mPEG-SH
English name: mPEG-SH
Chinese name: Methoxy polyethylene glycol - sulfhydryl; Polyethylene glycol monomethyl ether sulfhydryl
Molecular weight: usually between 1000 and 20000, the specific molecular weight can be customized according to needs, common 1k, 2k, 3.4k, 5k, 10k, 20k and other specifications.
Properties: Depending on the molecular weight, mPEG-SH can appear as a viscous liquid or a solid powder.
Solubility: mPEG-SH has good solubility and is soluble in water and most organic solvents.
2. Functional groups of mPEG-SH
The functional group of mPEG-SH is one of its core characteristics, which is mainly reflected in the following aspects:
Sulfhydryl (-SH) functional group:
Location: mPEG-SH contains sulfhydryl functional groups at the end of the molecular chain.
Reactivity: The sulfhydryl group has a strong nucleophilic property and can chemically react with a variety of molecules. For example, it can form a coordination bond with a metal ion, or it can react with another sulfhydryl group or other molecule containing a double bond to form a disulfide bond.
Application: The existence of sulfhydryl functional groups makes mPEG-SH have a wide range of applications in biomedical fields. It can be used to modify the surface of biological materials to improve the biocompatibility and stability of materials. It can also be used for the coupling of biological molecules to prepare biological couplings with specific functions; In addition, the sulfhydryl group can also be used as a reaction site for the preparation of biomaterials containing disulfide bonds for controlling the binding and release of biomolecules.
Methoxy (-OCH3) functional group:
Location: The other end of the molecular chain of mPEG-SH is the methoxy functional group.
Properties: Methoxy group makes mPEG-SH have a certain lipophilicity, which helps its distribution and metabolism in vivo.
3. Application fields of mPEG-SH
Biomedical field: mPEG-SH has a wide range of applications in the biomedical field. It can be used in the construction of drug delivery system to improve the solubility and stability of drugs. It can also be used for vector modification in gene therapy to improve the transfection efficiency and biocompatibility of the vector. In addition, it has potential applications in areas such as bioimaging and tissue engineering.
Materials science: mPEG-SH can also be used to prepare surface modification materials with specific functions, such as anti-fouling coatings, biosensors, etc.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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