mPEG-SSA (Methoxypolyethylene glycol succinimide succinate) is an important polyethylene glycol derivative with amino reactivity and is commonly used in biocoupling and materials science fields. Here is a detailed description of mPEG-SSA:
Structure composition: MPEG-SSA is composed of methoxy polyethylene glycol (mPEG) and succinimide succinate group. The PEG chain gives it good water solubility and biocompatibility, while the succinimide group is highly reactive.
Reactivity: At pH 7~8.5, the NHS ester group of mPEG-SSA can react with the primary amine group (-NH₂) to form a stable amide bond.
Solubility: mPEG-SSA is soluble in water and a variety of organic solvents (such as DMF, DMSO, etc.), with good solubility.
Physical state: Its physical state depends on the molecular weight and is usually solid or liquid.
Stability: mPEG-SSA has good stability under physiological conditions and is suitable for a variety of experiments and applications.
Application field
Biological coupling: mPEG-SSA can be used to link proteins, peptides, antibodies and other biomolecules together to form complexes with specific functions.
Drug delivery: By binding to drug molecules, mPEG-SSA can extend drug circulation time in the body, reduce degradation, and improve bioavailability.
Materials science: It can be used to prepare biocompatible biomaterials (such as biological scaffolds, slow-release carriers) and nanomaterials, which are widely used in tissue engineering and regenerative medicine.
Preservation and use
Storage conditions: It is recommended to store at -20 ° C away from light to avoid repeated freezing and thawing.
Precautions for use: Use it on the spot to avoid long-term exposure to the air.
mPEG-SSA is a multifunctional PEG derivative, which is widely used in biomedical and material science fields, and has important research and application value.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
|
mPEG-NH2
|
3-arm PEG-OH
|
|
mPEG-CM
|
3-arm PEG-NH2
|
|
mPEG-SA
|
3-arm PEG-CM
|
|
mPEG-SH
|
3-arm PEG-SH
|
|
mPEG-pALD
|
3-arm PEG-SC
|
|
mPEG-MAL
|
3-arm PEG-N3
|
|
mPEG-SC
|
3-arm PEG-NH2·HCl
|
|
mPEG-NPC
|
4-arm PEG-OH
|
|
mPEG-SS
|
4-arm PEG-NH2
|
|
mPEG-N3
|
4-arm PEG-CM
|
|
mPEG-AA
|
4-arm PEG-SA
|
|
mPEG-MA
|
4-arm PEG-SH
|
|
mPEG-VS
|
6-arm PEG-OH
|
|
mPEG-NH2·HCl
|
6-arm PEG-NH2
|
|
2-arm PEG-OH
|
6-arm PEG-CM
|
|
2-arm PEG-COOH
|
6-arm PEG-SA
|
|
2-arm PEG-NHS
|
6-arm PEG-SH
|
|
2-arm PEG-MAL
|
8-arm PEG-NH2
|
|
2-arm PEG-NH2
|
8-arm PEG-CM
|
|
2-arm PEG-Acetal
|
8-arm PEG-SA
|
|
2-arm PEG-CHO
|
8-arm PEG-SH
|
|
2-arm PEG-N3
|
8-arm PEG-pALD
|
