Novel Y-Shape PEGs with the functional group at only one terminal (out of three branch chains) is developed on the basis of V-Shape PEGs. Branched structure can provide an "umbrella-like" protective coverage around protein surface and maintain the reactivity of protein drugs in vivo effectively. Normally 2-arm branched PEG has a great sreric effect which brings high consumption in the linking reaction, while in Y-Shape PEG the distance between the functional group and the brabch point can be regulated to balance the steric effect and the reactivity. 

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