We are delighted to announce that SINOPEG will be participating in the LNP Formulation & Process Development Summit 2024 Agreement, scheduled to take place on April 29, 2024, in Boston, USA. This prestigious exhibition offers a unique platform for industry professionals to gather and exchange valuable insights on the latest advancements in LNP formulation and process development. We extend a warm welcome to everyone interested in this field to join us at this exciting event. Powered by latest developments with LNP CRISPR gene editing in the lungs, Bayer and Acuitas uniting to strengthen their Gene Therapy portfolio, new biotech ReNAgade Therapeutics launching with $300m Series A financing, lipid nanoparticles continue to dominate biopharma pipelines in 2024 and beyond as the most successful non-viral delivery vehicle to date. Moving into novel applications from gene therapy and cell therapy, and new disease indications from oncology to rare disease, LNP are equipping scientists with the ability to deliver transformative medicines to patients. With industry at a critical inflection point as a need to demonstrate clinical advancements for confidence to advance pipelines in 2024, the 3rd LNP Formulation & Process Development Summit will unite again in April with 4 tracks of carefully curated content as the industry’s one-stop-shop to evaluate and optimize LNPs end-to-end development for your given target of interest. *60+ expert speakers pioneering the next generation of LNP drug products *Content from early-stage discovery through the commercialized manufacture at large scale *A plethora of payloads, disease indications and route of administration *8 in-depth workshops, LNP 101 focus day, IP Patenting & Commercial Partnerships focus day, and 10+ hours of dedicated networking *Countless new topics, new speakers and new companies Date: April 29, 2024 Location:Boston, USA For more information and registration details, please visit the official website of the LNP Formulation & Process Development Summit 2024 Agreement. The LNP Formulation & Process Development Summit 2024 Agreement in Boston is an event not to be missed for professionals in the field of LNP formulation and process development.  We look forward to welcoming you to this exciting exhibition, where we can collectively contribute to the advancement of this rapidly evolving field. See you there!

Research Article | Issue | Published: 06 December 2016 Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging Mei Chen1,§, Shuzhen Chen2,3,§, Chengyong He2,§, Shiguang Mo1, Xiaoyong Wang2, Gang Liu2, Nanfeng Zheng1 Abstract Two-dimensional (2D) nanosheets have emerged as an important class of nanomaterial with great potential in the field of biomedicines, particularly in cancer theranostics.   However, owing to the lack of effective methods that synthesize uniform 2D nanomaterials with controlled size, systematic evaluation of size-dependent bio-behaviors of 2D nanomaterials is rarely reported.   To the best of our knowledge, we are the first to report a systematic evaluation of the influence of size of 2D nanomaterials on their bio-behaviors.   2D Pd nanosheets with diameters ranging from 5 to 80 nm were synthesized and tested in cell and animal models to assess their size-dependent bioapplication, biodistribution, elimination, toxicity, and genomic gene expression profiles.   Our results showed size significantly influences the biological behaviors of Pd nanosheets, including their photothermal and photoacoustic effects, pharmacokinetics, and toxicity.   Compared to larger-sized Pd nanosheets, smaller-sized Pd nanosheets exhibited more advanced photoacoustic imaging and photothermal effects upon ultralow laser irradiation.   Moreover, in vivo results indicated that 5-nm Pd nanosheets escape from the reticuloendothelial system with a longer blood half-life and can be cleared by renal excretion, while Pd nanosheets with larger sizes mainly accumulate in the liver and spleen.   The 30-nm Pd nanosheets exhibited the highest tumor accumulation.   Although Pd nanosheets did not cause any appreciable toxicity at the cellular level, we observed slight lipid accumulation in the liver and inflammation in the spleen.   Genomic gene expression analysis showed that 80-nm Pd nanosheets interacted with more cellular components and affected more biological processes in the liver, as compared to 5-nm Pd nanosheets.   We believe this work will provide valuable information and insights into the clinical application of 2D Pd nanosheets as nanomedicines. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Biomaterials. 2018 Mar:158:23-33.   doi: 10.1016/j.biomaterials.2017.12.009.   Epub 2017 Dec 13. Rattle-type Au@Cu2-xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy Yu Cao 1, Shuzhou Li 2, Chao Chen 2, Dongdong Wang 1, Tingting Wu 1, Haifeng Dong 3, Xueji Zhang 4 Abstract The coupling of the localized surface plasma resonance (LSPR) between noble metals of Au, Ag and Cu and semiconductors of Cu2-xE (E = S, Se, Te) opens new regime to design photothermal (PT) agents with enhanced PT conversion efficiency.   However, it is rarely explored on fabricating of engineered dual plasmonic hybrid nanosystem for combinatory therapeutic-diagnostic applications.   Herein, rattle-type Au@Cu2-xS hollow mesoporous nanoparitcles with advanced PT conversion efficiency are designed for cellular vehicles and chemo-photothermal synergistic therapy platform.   The LSPR coupling between the Au core and Cu2-xS shell are investigated experimentally and theoretically to generate a PT conversion efficiency high to 35.2% and enhanced by 11.3% than that of Cu2-xS.   By conjugating microRNA (miRNA) gene probe on the surface, it can realize the intracellular oncogenic miRNA detection.   After loading of anticancer drug doxorubicin into the cavity of the Au@Cu2-xS, the antitumor therapy efficacy is greatly enhanced in vitro and in vivo due to the NIR photoactivation chemo- and photothermal synergistic therapy.   The rattle-type metal-semiconductor hollow mesoporous nanostructure with efficient LSPR coupling and high cargo loading capability will be beneficial to future design of LSPR-based photothermal agents for a broad range of biomedical application. Keywords: Chemo-photothermal therapy;   Localized surface plasma resonance coupling;   MicroRNA detection;   Rattle-type Au@Cu(2−x)S;   Theranostic platform. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Chem Sci. 2018 Apr 12;9(18):4268-4274.  doi: 10.1039/c8sc00104a.  eCollection 2018 May 14. Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy Mei Chen 1 2, Zhide Guo 3, Qinghua Chen 4, Jingping Wei 1, Jingchao Li 1, Changrong Shi 3, Duo Xu 3, Dawang Zhou 4, Xianzhong Zhang 3, Nanfeng Zheng 1 Abstract Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy.  However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges.  Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of 131I and 125I on their surfaces (denoted as 131I-Pd-PEG or 125I-Pd-PEG).  Systematic studies reveal that the labeling efficiency is higher than 98% and the adsorption of radioiodine is more stable in an acidic environment.  In vivo studies further validate the pH-dependent behavior of this platform and the enhanced retention of radioisotopes in tumors due to the acidic microenvironment.  Single photon emission computed tomography (SPECT) images with zero background were successfully achieved in a subcutaneous 4T1 tumor model, an orthotopic LM3 tumor model, and even in a Mst1/2 double-knockout hepatoma model.  Moreover, the application of radiolabeled Pd nanosheets for photoacoustic (PA) imaging, and combined photothermal and radiotherapy was also explored.  Therefore, this study provides a simple and efficient strategy to solve the critical high background issue of radiolabeled nanoparticles and shows enormous potential for clinical applications. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Int J Pharm. 2016 Jan 30;497(1-2):210-21. doi: 10.1016/j.ijpharm.2015.11.032. Epub 2015 Dec 1. Nanocomposite hydrogel incorporating gold nanorods and paclitaxel-loaded chitosan micelles for combination photothermal-chemotherapy Nan Zhang 1, Xuefan Xu 1, Xue Zhang 1, Ding Qu 1, Lingjing Xue 2, Ran Mo 1, Can Zhang 3 Abstract Development of combination photothermal-chemotherapy platform is of great interest for enhancing antitumor efficacy and inhibiting tumor recurrence, which supports selective and dose-controlled delivery of heat and anticancer drugs to tumor. Here, an injectable nanocomposite hydrogel incorporating PEGylated gold nanorods (GNRs) and paclitaxel-loaded chitosan polymeric micelles (PTX-M) is developed in pursuit of improved local tumor control. After intratumoral injection, both GNRs and PTX-M can be simultaneously delivered and immobilized in the tumor tissue by the thermo-sensitive hydrogel matrix. Exposure to the laser irradiation induces the GNR-mediated photothermal damage confined to the tumor with sparing the surrounding normal tissue. Synergistically, the co-delivered PTX-M shows prolonged tumor retention with the sustained release of anticancer drug to efficiently kill the residual tumor cells that evade the photothermal ablation due to the heterogeneous heating in the tumor region. This combination photothermal-chemotherapy presents superior effects on suppressing the tumor recurrence and prolonging the survival in the Heps-bearing mice, compared to the photothermal therapy alone. Keywords: Chemotherapy; Chitosan micelles; Combination therapy; Gold nanorod; Photothermal therapy. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2017 Sep 13;9(36):31153-31160.   doi: 10.1021/acsami.7b09529.   Epub 2017 Aug 30. Mixed Self-Assembly of Polyethylene Glycol and Aptamer on Polydopamine Surface for Highly Sensitive and Low-Fouling Detection of Adenosine Triphosphate in Complex Media Guixiang Wang 1 2, Qingjun Xu 1, Lei Liu 1, Xiaoli Su 1, Jiehua Lin 1, Guiyun Xu 1, Xiliang Luo 1 Abstract Detection of disease biomarkers within complex biological media is a substantial outstanding challenge because of severe biofouling and nonspecific adsorptions.   Herein, a reliable strategy for sensitive and low-fouling detection of a biomarker, adenosine triphosphate (ATP) in biological samples was developed through the formation of a mixed self-assembled sensing interface, which was constructed by simultaneously self-assembling polyethylene glycol (PEG) and ATP aptamer onto the self-polymerized polydopamine-modified electrode surface.   The developed aptasensor exhibited high selectivity and sensitivity toward the detection of ATP, and the linear range was 0.1-1000 pM, with a detection limit down to 0.1 pM.   Moreover, owing to the presence of PEG within the sensing interface, the aptasensor was capable of sensing ATP in complex biological media such as human plasma with significantly reduced nonspecific adsorption effect.   Assaying ATP in real biological samples including breast cancer cell lysates further proved the feasibility of this biosensor for practical application. Keywords: adenosine triphosphate;   antifouling;   aptasensor;   cancer cell lysates;   polydopamine;   polyethylene glycol. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Happy New Year! Wishing you all a year filled with joy, success, and endless possibilities. May this new year bring you happiness and fulfillment in everything you do. Let's embrace new beginnings and make the most of every moment. Cheers to a fantastic year ahead! #NewYear #2024

Sci Rep. 2017 Mar 31:7:45633.  doi: 10.1038/srep45633. Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers Yulei Chang 1, Xiaodan Li 1 2, Li Zhang 1 2, Lu Xia 1, Xiaomin Liu 1, Cuixia Li 1, Youlin Zhang 1, Langping Tu 1 3, Bin Xue 1 3, Huiying Zhao 2, Hong Zhang 3, Xianggui Kong 1 Abstract Recent advances in upconversion nanophotosensitizers (UCNPs-PS) excited by near-infrared (NIR) light have led to substantial progress in improving photodynamic therapy (PDT) of cancer.  For a successful PDT, subcellular organelles are promising therapeutic targets for reaching a satisfactory efficacy.  It is of vital importance for these nanophotosensitizers to reach specifically the organelles and to perform PDT with precise time control.  To do so, we have in this work traced the dynamic subcellular distribution, especially in organelles such as lysosomes and mitochondria, of the poly(allylamine)-modified and dual-loaded nanophotosensitizers.  The apoptosis of the cancer cells induced by PDT with the dependence of the distribution status of the nanophotosensitizers in organelles was obtained, which has provided an in-depth picture of intracellular trafficking of organelle-targeted nanophotosensitizers.  Our results shall facilitate the improvement of nanotechnology assisted photodynamic therapy of cancers. Related products Abbreviation: mPEG-SC Name: Methoxypoly(ethylene glycol) succinimidyl carbonate For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com