Graphene, as the thinnest, strongest and stiffest material and arranged in a honeycomb pattern structure with sp2-hybridized carbon, finds more potential applications in modern industry than other carbonaceous allotropes; in pristine form, it is also an excellent heat and electric conductor . However, the major obstacle in utilizing graphene, particularly for electronic applications, is its insolubility in the fully reduced state due to the strong affinity between the graphene sheets. In the present study, they synthesized for the first time a polydispersed graphene with desirable electric conductivity by covalent functionalization with single terminal aminated polyethylene glycol monomethyl ether (PEG-NH2). The PEG-NH2 grafted graphene (PEG@GO) was then reduced by hydrazine hydrate to PEG@rGO and subsequently incorporated into epoxy resin by a solution mixing method. The PEG@rGO with a“core-shell”structure exhibited homogeneous dispersion in epoxy and also effectively reduced the dielectric loss, hence contributing excellent dielectric properties and mechanical strength to the final PEG@rGO/epoxy nanocomposites. Fig. 1. Low and high magnification SEM images of (a, a’) neat epoxy, (b, b’) PEG@rGO/epoxy 1.0 wt%, and (c, c’) rGO/epoxy 1.0 wt% nanocomposites. Dielectric properties of PEG@rGO/epoxy nanocomposite. Fig. 1 displays representative SEM images of neat epoxy, PEG@rGO/epoxy and rGO/epoxy nanocomposites. The surface of neat epoxy (Fig. 1a and a') displays a typical smooth structure characteristic of its brittleness. The modified PEG@rGO exhibits excellent dispersion in epoxy (black arrows in Fig. 1b) and no obvious aggregates of PEG@rGO are observed. The magnified SEM image of PEG@rGO/epoxy (see Fig. 1b’) reveals some PEG@rGO nanosheets pulled out or dragged from epoxy and also confirms strong interfacial filler/matrix interaction due to the filler surface functionalization. By contrast, untreated graphene (rGO) nanoplatelets aggregate easily in epoxy matrix caused by the inert surface of reduced graphene as demonstrated in Fig.1c and c', yielding poor mixing and dispersion of rGO. Therefore, the excellent dispersion of PEG@rGO compared to untreated rGO results in enhanced dielectric and mechanical properties of the nanocomposites discussed in the next two sub-sections. Fig. 2. Dispersion state of (a) PEG@GO and (b) PEG@rGO in different solvents after different times. It is known that pristine graphene is extremely insoluble in water and other organic solvents, while GO exhibits polydispersed behavior due to the formation of plenty of hydrophilic oxygen groups. The solubility of PEG@GO and PEG@rGO in different solvents are displayed in Fig.2. As expected, PEG@GO shows good compatibility in water, alcohol, acetone and DMF even after 1 week. The good dispersion of PEG@GO is mainly attributed to the oxygen groups at its edges and basal plane. After reduction, PEG@rGO is less soluble than PEG@GO, especially in alcohol and acetone. ...

According to statistics, the number of diabetes patients in the world has reached 425 million in 2017.It is estimated that the number of diabetes patients in the world will reach 629 million in 2045.Diabetes medicine is one of the largest drug markets in the world.Among them, injection medicine  (insulin, GLP-1) totaled 29 billion US dollars, accounting for 69%; oral preparations (DPP-4, SGLT-2) totaled US $13 billion, accounting for 31%. Semaglutide is a human GLP-1 analogue currently in development for the treatment of T2D, with a similar structure to liraglutide. Semaglutide reduces HbA1c, systolic blood pressure, and body weight.After 12 weeks of treatment, semaglutide decreased fasting and postprandial glucose by increasing insulin production and decreasing glucagon secretion (which is normally associated with increases in blood sugar). Semaglutide also lowers fasting triglycerides and VLDL cholesterol, exerting beneficial effects on cardiovascular health. In Novo Nordisk's half year 2020 financial report, semaglutide injection (Ozempic) has been listed in 43 countries around the world.In the first half of 2020, sales increased by 152% to US $1.5 billion. Sales of liraglutide (Victoza) fell 18% to $1.47 billion. In addition, sales of oral semaglutide (Rybelsus) just approved in 2019 will reach US $92 million. According to the prediction of Evaluate Pharma, GLP-1 and SGLT-2 will occupy half of the world's top 10 hypoglycemic drugs in 2024. Global sales of semaglutide injection(Ozempic) are expected to reach $5.28 billion by 2024, and oral semaglutide (Rybelsus) is expected to reach $3.23 billion. If there is any copyright infringement, please contact us and we will remove the content at the first time. Sinopeg provide semaglutide and liraglutide. The product has high purity and complete quality system, which can meet the clinical application. If you need help, please contact us!

Tissue adhesives play a vital role in surgical processes as a substitute for sutures in wound closure. Tissue adhesives, have been widely used in dentistry , orthopedics , and cardiovascular wounds closure to partially replace the traditional suturing approaches that often induce tissue deformation, irregular blood flow, and wound dehiscence. However, many of the existing commercial tissue adhesives have flaws that become evident upon application. For example, cyanoacrylate (Super Glue), which is considered as the strongest tissue adhesive,  has been shown to possess strong cytotoxicity . Fibrin glueand polyethylene glycol adhesivesare widely used due to their fast closure and biodegradability .  However, both types of glue have limited applications due to their poor tissue-adhesive property and tensile strength. This study present click chemistry enhanced, dual-crosslinked CS bioadhesive as a new strategy for wound closure with strong adhesive strength, injectability, and biocompatibility. In detail, CS-TCO and CS-Tz precursors were synthesized through carboxyl-to-amine crosslinking (Scheme 1). Upon administration, 4-arm PEG-PALD was mixed with one of the precursors and both of the precursors were injected and mixed within the wound (Scheme 1, 2). The crosslinking of the CS was through both, the rapid reaction between conjugated click chemistry pair TCO/Tz and the formation of Schiff bases between PEG-PALD and primary amines on CS. The mixture can form a solid hydrogel within 2 minutes. By optimizing the dosage of the co-crosslinker, adhesive strength, rheology, swelling ratio, and pore size of the hydrogel were characterized and compared, and the recipe that had the strongest adhesive strength was chosen for further animal study. Scheme 1. Step-by-step synthesis of the precursors and crosslinking of CS bioadhesives. Scheme 2. A depiction of the bonding structure between the CS bioadhesives and surrounding tissue. In this study, click chemistry-based CS bioadhesives were fabricated and evaluated for their ability to accelerate wound closure and promote wound healing. By taking advantage of the rapid click chemistry reaction time, they are able to tune the gelation time of the CS bioadhesives to be around 60-70 seconds for various clinical applications. Through introducing Schiff bases formed within the CS bioadhesives and between the CS bioadhesives and the surrounding tissue, the adhesive strength of the CS bioadhesives was significantly elevated. With the optimized formulation, the adhesive strength of the CS bioadhesives was 2.3 folds higher than that of fibrin glue. The quantitative in vitro cytotoxicity evaluations of the CS bioadhesives supported the application of this material in the medical field. Finally, with the application of the CS bioadhesives for wound closure in mice, it showed that the material produced small tissue gap, accelerated wound closure, and led to a better healing outcome compared with t...

A sealant can significantly improve the effect of visceral surgery; it can not only reduce intraoperative blood loss, but also reduce postoperative complications such as secondary hemorrhage and tissue adhesion, which are essential in surgical operations. However, the sealant currently used for in vivo hemostasis cannot address the needs in the modern aging society. The main challenges are its safeness, easiness of preparation and removal, and price. The commercial synthetic sealants are mainly made up of PEG, for example the 4-arm PEG hydrogel based on the ammonolysis reaction. Those sealants have advantages of high strength, strong adhesion and economic price, but the disadvantage is that they cannot be quickly degraded and can easily cause foreign body reaction in the wound that leads to healing delay. In order to overcome the limitations of the existing PEG hydrogels, a new PEG sealant based on multi-arm PEG Succinimidyl Succinate (amide bond) has been jointly developed by Institute of Chemistry, Chinese Academy of Science and the General Hospital of People's Liberation Army. The in vitro experiments show that SS glue has a better hemostatic effect than the previously developed SG and gauze. SS can quickly stanch the bleeding on the wound as well as prevent the adhesion issue after the operation. In contrast, SG and gauze both have different degree of postoperative adhesion when they are used for hemostasis. However, this is not the case for SS, as it is able to stop bleeding effectively even for patients taking anticoagulants, which cannot be achieved by the widely used fibrin glue. The researchers compare the hemostatic effects of SS, SG and gauze on wounds. Among them, SS and SG can achieve rapid wound hemostasis, while gauze is much slower. And after a week of hemostasis, both SG and gauze have different degrees of adhesion while SS does not have such side effects. It indicates that SS not only can stop bleeding, but also acts as a physical barrier to prevent the wound from adhering to the surrounding tissues during the healing process (Figure a). Figure b compares the healing situation of wounds at different times after surgery. Figure c compares the separate hemostatic effects of SS and fibrin glue used in the wounds of a New Zealand white rabbit with anticoagulants. SS has a better hemostatic effect than fibrin glue in terms of speed and stability. The author further uses SS to perform the hemostasis experiment on a large wound surface (diameter: 25mm, depth: 10mm). Even if a coagulant is used, SS can effectively stop bleeding after a certain period of time. [1] Bu Y ,  Zhang L ,  Sun G , et al. Tetra㏄EG Based Hydrogel Sealants for In Vivo Visceral Hemostasis[J]. Advanced Materials, 2019, 31(28):1901580.1-1901...

Exposure of dentinal tubules (DTs) leads to the transmission of external stimuli within the DTs, causing dental hypersensitivity (DH). Approximately 42% 18- to 35-year-olds experience dental hypersensitivity (DH), which is characterized by a short or transient sharp pain arising from exposed dentin. To treat DH, various desensitizers have been developed for occluding DTs. However, most desensitizers commercially available or in development are only able to seal the orifices, rather than the deep regions of the DTs, thus lacking long-term stability. Dr. C. Li, Prof. P. Yang found it is shown that the fast amyloid-like aggregation of lysozyme (lyso) conjugated with poly(ethylene glycol) (PEG) (lyso-PEG) can afford a robust ultrathin nanofilm on the deep walls of DTs through a rapid one-step aqueous coating process (in 2 min). The resultant nanofilm provides a highly effective antifouling platform for resisting the attachment of oral bacteria such as Streptococcus mutans and induces remineralization in the DTs to seal both the orifices and depths of the DTs by forming hydroxyapatite (HAp) minerals in situ. Both in vitro and in vivo animal experiments prove that the nanofilm-coated DTs are occluded with a depth of over 60 ± 5 µm, which is at least 6 times deeper than that reported in the literature. This approach thus demonstrates the concept that an amyloid-like proteinaceous nanofilm can offer an inexpensive, rapid, and efficient therapy for treating DH with long-term effect. Sinopeg provide various NW poly(ethylene glycol) (PEG) products: 2KDa, 5KDa, 10KDa, 20KDa, etc. Products: Linear Monofunctional PEGs Linear Bifunctional PEGs Linear Heterofunctional PEGs Branched PEGs Multi-Arm Functional PEGs Functionally Grafted PEGs

CPhI Worldwide 2019 was held successfully in Frankfurt, Germany from Nov. 5th-7th. SINOPEG's CEO Dr. Wengui Weng and sales manager Mr. Lingnan Chen attended this exhibition. Our booth Number is 41K60. We SINOPEG was established in 2011, and specilized in PEG derivatives, PEG block-copolymer, side chain of diabetes medications etc.. We are not only maintain the advantage of old products, but also continue to work on the development of new products.   During the exhibition, many customers visited our booth. We had very deep discusstion with our old customers and partners regarding some issues and problems of ongoing projects, and reached agreements for the further programs. Besides, we also received many new potential customers from all over the world. They showed great interest in our products, and made preliminary cooperation intention with us. Thanks very much for the support and trust from all friends, customers and partners! We hope we can have close cooperation together, and reach win-win achievement in the future.

Tetra-PEG hydrogels based on the ammonolysis reaction between tetra-armed poly(ethylene glycol) amine (Tetra-PEG-NH2) and Tetra-PEG-SAE offer massive advantages as sealants. They are entirely synthetic without the misgivings of being inhibited by anticoagulation agents and transferring disease. Their cost is low due to their easily preservable components with high accessibility. Because of the intrinsic properties of this ammonolysis reaction, the resulting hydrogels can gel  fast just by injection and adhere to the tissues tightly throughchemical bonds. Another remarkable advantage for Tetra-PEG hydrogels is that they are mechanically tough, and the sealants are favored to be mechanically tough to keep stable in case of dynamic movement of the tissues and the use of assistant pressure which is a key adjunctive step in achieving hemostasis. However, two hurdles are preventing extending their applications in vivo. The first one is that just as commercialized sealants, none of the reported Tetra-PEG hydrogels could be controllably removed without mechanical debridement, which is extremely dangerous because of their high mechanical strength. Besides, they possess long degradation time, which will lead to severe foreign body reactions, tissue adhesion, disturbed tissue healing, and obstruction of the circulatory system, when used in vivo. Here, to overcome the limitations of the existing ammonolysis based Tetra-PEG hydrogels, we construct an optimized one (SS) with fast degradable and controllably dissolvable properties via Tetra-PEG-NH2 and tetra-armed poly(ethylene glycol) succinimidyl succinate (Tetra-PEG-SS) . The resulting SS exhibits biocompatibility superior to the reported degradable Tetra-PEG hydrogel (SG) based on Tetra-PEG-NH2 and tetra-armed poly(ethylene glycol) succinimidyl glutarate (Tetra-PEG-SG) . More importantly, in contrast to the disappointing results of SG that leads to serious adverse effects in in vivo hemostasis due to the long retention, SS causes almost no noticeable side effects with outstanding hemostasis efficacy even under the anticoagulated situations. This hydrogel is a promising candidate for the next-generation in vivo sealants in the aged society.

CPhI China 2019 was held successfully in Shanghai, China from June 18th-20th. We Sinopeg sent a very professional sales team to participate this exhibition. Our booth Number is W4F21. During the exhibition, we had very deep disscuion with old partner, and customers from all over the world came to  consult the company's products，we obtained the approval and praise from our customers. Looking forward to see you again next year, CPhI China 2020 in Shanghai.