Biomaterials. 2017 Oct:141:116-124. doi: 10.1016/j.biomaterials.2017.06.030. Epub 2017 Jun 27.
Autophagy inhibition enabled efficient photothermal therapy at a mild temperature
Zhengjie Zhou 1, Yang Yan 1, Kewen Hu 1, Yuan Zou 2, Yiwen Li 2, Rui Ma 1, Qiang Zhang 3, Yiyun Cheng 4
Abstract
The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal therapy commonly results in incomplete tumor eradication and serious damage of health tissue. Here, we found autophagy was activated in cancer cells underwent photothermal therapy and the inhibition of autophagy significantly enhanced the efficacy of photothermal killing of cancer cells. A formulation of chloroquine-loaded polydopamine nanoparticles was developed for sensitized photothermal cancer therapy, and the in vitro and in vivo study demonstrated that inhibition of autophagy remarkably augmented the efficacy of photothermal therapy, leading to efficient tumor suppression at a mild temperature. The regulation of autophagy provides a new route to increase the efficacy of photothermal cancer therapy.
Keywords: Autophagy; Chloroquine; Photothermal therapy; Polydopamine nanoparticles; Sensitization.
Related products
Abbreviation: mPEG-SH
Name: Methoxypoly(ethylene glycol) thiol
Abbreviation: H2N-PEG-SH
Name: α-Amino-ω-mercapto poly(ethylene glycol)
For more product information, please contact us at:
US Tel: 1-844-782-5734
US Tel: 1-844-QUAL-PEG
CHN Tel: 400-918-9898
Email: sales@sinopeg.com
