Industry News
  • Core-shell structured polyethylene glycol functionalized graphene for energy-storage polymer dielectrics: Combined mechanical and dielectric performances
    Core-shell structured polyethylene glycol functionalized graphene for energy-storage polymer dielectrics: Combined mechanical and dielectric performances September 1,2020.
    Graphene, as the thinnest, strongest and stiffest material and arranged in a honeycomb pattern structure with sp2-hybridized carbon, finds more potential applications in modern industry than other carbonaceous allotropes; in pristine form, it is also an excellent heat and electric conductor . However, the major obstacle in utilizing graphene, particularly for electronic applications, is its insolubility in the fully reduced state due to the strong affinity between the graphene sheets. In the present study, they synthesized for the first time a polydispersed graphene with desirable electric conductivity by covalent functionalization with single terminal aminated polyethylene glycol monomethyl ether (PEG-NH2). The PEG-NH2 grafted graphene ([email protected]) was then reduced by hydrazine hydrate to [email protected] and subsequently incorporated into epoxy resin by a solution mixing method. The [email protected] with a“core-shell”structure exhibited homogeneous dispersion in epoxy and also effectively reduced the dielectric loss, hence contributing excellent dielectric properties and mechanical strength to the final [email protected]/epoxy nanocomposites. Fig. 1. Low and high magnification SEM images of (a, a’) neat epoxy, (b, b’) [email protected]/epoxy 1.0 wt%, and (c, c’) rGO/epoxy 1.0 wt% nanocomposites. Dielectric properties of [email protected]/epoxy nanocomposite. Fig. 1 displays representative SEM images of neat epoxy, [email protected]/epoxy and rGO/epoxy nanocomposites. The surface of neat epoxy (Fig. 1a and a') displays a typical smooth structure characteristic of its brittleness. The modified [email protected] exhibits excellent dispersion in epoxy (black arrows in Fig. 1b) and no obvious aggregates of [email protected] are observed. The magnified SEM image of [email protected]/epoxy (see Fig. 1b’) reveals some [email protected] nanosheets pulled out or dragged from epoxy and also confirms strong interfacial filler/matrix interaction due to the filler surface functionalization. By contrast, untreated graphene (rGO) nanoplatelets aggregate easily in epoxy matrix caused by the inert surface of reduced graphene as demonstrated in Fig.1c and c', yielding poor mixing and dispersion of rGO. Therefore, the excellent dispersion of [email protected] compared to untreated rGO results in enhanced dielectric and mechanical properties of the nanocomposites discussed in the next two sub-sections. Fig. 2. Dispersion state of (a) [email protected] and (b) [email protected] in different solvents after different times. It is known that pristine graphene is extremely insoluble in water and other organic solvents, while GO exhibits polydispersed behavior due to the formation of plenty of hydrophilic oxygen groups. The solubility of [email protected] and [email protected] in different solvents are displayed in Fig.2. As expected, [email protected] shows good compatibility in water, alcohol, acetone and DMF even after 1 week. The good dispersion of [email protected] is mainly attributed to the oxygen groups at its edges and basal plane. After reduction, [email protected] is less soluble than [email protected], especially in alcohol and acetone. ...
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  • Sales of semaglutide increased by 152%!
    Sales of semaglutide increased by 152%! August 11,2020.
    According to statistics, the number of diabetes patients in the world has reached 425 million in 2017.It is estimated that the number of diabetes patients in the world will reach 629 million in 2045.Diabetes medicine is one of the largest drug markets in the world.Among them, injection medicine  (insulin, GLP-1) totaled 29 billion US dollars, accounting for 69%; oral preparations (DPP-4, SGLT-2) totaled US $13 billion, accounting for 31%. Semaglutide is a human GLP-1 analogue currently in development for the treatment of T2D, with a similar structure to liraglutide. Semaglutide reduces HbA1c, systolic blood pressure, and body weight.After 12 weeks of treatment, semaglutide decreased fasting and postprandial glucose by increasing insulin production and decreasing glucagon secretion (which is normally associated with increases in blood sugar). Semaglutide also lowers fasting triglycerides and VLDL cholesterol, exerting beneficial effects on cardiovascular health. In Novo Nordisk's half year 2020 financial report, semaglutide injection (Ozempic) has been listed in 43 countries around the world.In the first half of 2020, sales increased by 152% to US $1.5 billion. Sales of liraglutide (Victoza) fell 18% to $1.47 billion. In addition, sales of oral semaglutide (Rybelsus) just approved in 2019 will reach US $92 million. According to the prediction of Evaluate Pharma, GLP-1 and SGLT-2 will occupy half of the world's top 10 hypoglycemic drugs in 2024. Global sales of semaglutide injection(Ozempic) are expected to reach $5.28 billion by 2024, and oral semaglutide (Rybelsus) is expected to reach $3.23 billion. If there is any copyright infringement, please contact us and we will remove the content at the first time. Sinopeg provide semaglutide and liraglutide. The product has high purity and complete quality system, which can meet the clinical application. If you need help, please contact us!
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  • Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure
    Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure July 30,2020.
    Tissue adhesives play a vital role in surgical processes as a substitute for sutures in wound closure. Tissue adhesives, have been widely used in dentistry , orthopedics , and cardiovascular wounds closure to partially replace the traditional suturing approaches that often induce tissue deformation, irregular blood flow, and wound dehiscence. However, many of the existing commercial tissue adhesives have flaws that become evident upon application. For example, cyanoacrylate (Super Glue), which is considered as the strongest tissue adhesive,  has been shown to possess strong cytotoxicity . Fibrin glueand polyethylene glycol adhesivesare widely used due to their fast closure and biodegradability .  However, both types of glue have limited applications due to their poor tissue-adhesive property and tensile strength. This study present click chemistry enhanced, dual-crosslinked CS bioadhesive as a new strategy for wound closure with strong adhesive strength, injectability, and biocompatibility. In detail, CS-TCO and CS-Tz precursors were synthesized through carboxyl-to-amine crosslinking (Scheme 1). Upon administration, 4-arm PEG-PALD was mixed with one of the precursors and both of the precursors were injected and mixed within the wound (Scheme 1, 2). The crosslinking of the CS was through both, the rapid reaction between conjugated click chemistry pair TCO/Tz and the formation of Schiff bases between PEG-PALD and primary amines on CS. The mixture can form a solid hydrogel within 2 minutes. By optimizing the dosage of the co-crosslinker, adhesive strength, rheology, swelling ratio, and pore size of the hydrogel were characterized and compared, and the recipe that had the strongest adhesive strength was chosen for further animal study. Scheme 1. Step-by-step synthesis of the precursors and crosslinking of CS bioadhesives. Scheme 2. A depiction of the bonding structure between the CS bioadhesives and surrounding tissue. In this study, click chemistry-based CS bioadhesives were fabricated and evaluated for their ability to accelerate wound closure and promote wound healing. By taking advantage of the rapid click chemistry reaction time, they are able to tune the gelation time of the CS bioadhesives to be around 60-70 seconds for various clinical applications. Through introducing Schiff bases formed within the CS bioadhesives and between the CS bioadhesives and the surrounding tissue, the adhesive strength of the CS bioadhesives was significantly elevated. With the optimized formulation, the adhesive strength of the CS bioadhesives was 2.3 folds higher than that of fibrin glue. The quantitative in vitro cytotoxicity evaluations of the CS bioadhesives supported the application of this material in the medical field. Finally, with the application of the CS bioadhesives for wound closure in mice, it showed that the material produced small tissue gap, accelerated wound closure, and led to a better healing outcome compared with t...
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