Industry News
  • Long-term injectable tetra-PEG@PEG-ALN hydrogel for osteoporosis
    Long-term injectable [email protected] hydrogel for osteoporosis March 29,2021.
    Osteoporosis is defined as a systemic and metabolic bone disease, which is characterized by a decrease in bone mass per unit volume and deterioration of the microstructure of bone tissue, thereby increasing bone fragility and susceptibility to fracture. With the increase in the proportion of elderly populations in the world, and in consequence the number of postmenopausal woman, sarcopenia and osteoporosis are important public health issues. Alendronate (ALN) is a kind of bisphosphonate, which is the most widely used medication in the treatment of skeletal disorders such as osteoporosis, due to its significant pharmacological effect of inhibition on bone resorption. However, the poor permeability exhibit extremely low bioavailability after oral administration (less than 1%). Furthermore, to avoid serious side effects caused by drug-food interactions, patients were instructed to take the medication orally in the morning at least 30 min before breakfast with abundant water and on an empty stomach after an overnight fast, and to remain upright for at least 30 min after dosing. To overcome the limitations of conventional treatments and provide better patient compliance, researchers from the Chinese Academy of Sciences and Zhengzhou University have jointly developed a minimally invasive procedures system for long-term injectable drug delivery, which is effective for clinical osteoporosis therapy (Scheme 1). They introduced PEGylated ALN (PEG-ALN) prodrug into the tetra-PEG hydrogel network, which limits the release rate of ALN because the PEG-ALN polymer does not move easily and freely in the 4 arm PEG hydrogel network, thus achieving slow drug release and local drug delivery, avoiding the serious side effects of systemic administration.
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  • SINOPEG COVID-19 Vaccine Excipients Supply
    SINOPEG COVID-19 Vaccine Excipients Supply February 5,2021.
    SINOPEG are Covid-19 Vaccine Excipient Supplier. Lots of the pharmaceutical companies keep developing the Covid-19 vaccine. Now there are two famous USA Vaccines in the market, we can produce and provide main vaccine excipients and have already been one of the main supplier for one of them. Here is our Covid-19 vaccine excipients list. list: ALC-0315 = ((4-hydroxybutyl) azanediyl) bis (hexane-6,1-diyl) bis (2-hexyldecanoate), CAS no. : 2036272-55-4 ALC-0159 = 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide 1,2-distearoyl-sn-glycero-3-phosphocholine, DSPC, CAS no. : 816-94-4 Polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG], mPEG2000-DMG, CAS no. : 160743-62-4 SM-102 (heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxO-6-(undecyloxy) hexyl) amino) octanoate) Methoxypoly(ethylene glycol) 2000, mPEG-OH Methoxypoly (ethylene glycol) propylamine 2000, mPEG-CH2CH2CH2-NH2 Methoxypoly(ethylene glycol) carboxymethyl 2000, mPEG-CM research use only
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    PROTAC LINKER January 25,2021.
    PROTAC (proteolysis targeting chimeras) is a kind of dual functional molecules. The PROTAC molecule is composed of three parts: one end is a ligand molecule binding to the target protein to be degraded, the other side is a ligand molecule binding to the E3 ubiquitination ligase, and the middle  is connected by a specific Linker. PROTAC molecules connect the target protein to be degraded with E3 ubiquitination ligases through the above ligands, thus enabling the target protein to be ubiquitinated and further degraded by proteasomes. PROTAC, on the other hand, is not degraded by the proteasome and can be reused. Compared with common small molecule inhibitors, PROTAC molecule catalyzes protein degradation function in a way independent of occupation-driven, showing excellent high selectivity and low toxicity, and can effectively overcome the resistance of traditional small molecule inhibitors. PEG has been widely used as PROTAC Linker! The monodisperse polyethylene glycol derivative produced SINOPEG is the high quality choice of this kind of PROTAC Linker! Welcome to communicate with us!
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