Name and structure

English name: N3-PEG24-NHS

Structure: The compound contains an azide group (N3-), a polyethylene glycol chain (PEG), where the molecular weight or chain length of PEG may be expressed as 24, but usually the molecular weight of PEG will be expressed by a specific number, such as 1k, 2k, etc., where "24" may be a special mark or abbreviation. Further confirmation is needed) and N-hydroxysuccinimide groups (NHS).

Nature and function

1. Reaction activity:

The azide group (N3-) is a highly reactive functional group that can perform efficient Click Chemistry with compounds containing unsaturated bonds such as alkynes and terminal alkenes, such as the CuAAC catalyzed azide-alkyne cycloaddition reaction.

The N-hydroxysuccinimide group (NHS) is an activated ester that can react with amine compounds (such as proteins, peptides, etc.) to form stable amide bonds.

2. Water solubility and biocompatibility:

The introduction of polyethylene glycol (PEG) chains can increase the water solubility of biomolecules, reduce non-specific adsorption, and extend their circulation time in the body.

N3-PEG24-NHS, as a PEG derivative, usually has good water solubility and biocompatibility.

3. Application:

N3-PEG24-NHS can be used for the labeling, modification and coupling of biomolecules, especially with biomolecules containing amino groups (such as proteins, antibodies, peptides, etc.).

The compound has potential application value in biomedicine, biotechnology and other fields, such as preparing functionalized PEG-modified biomolecules for cell targeting, biological imaging and other studies.

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