The functional group of mPEG-GAA is mainly composed of PEG segment, C4 fatty amide bond and carboxyl group (COOH). The PEG segment is a hydrophilic polymer chain with good biocompatibility and stability. The C4 fatty amide bond is the key part connecting PEG segment and carboxyl group, which gives mPEG-GAA specific chemical properties and reactivity.
2. Functional group characteristics
Hydrophilicity and biocompatibility: mPEG-GAA has good hydrophilicity and biocompatibility due to the presence of PEG chain segments. This enables mPEG-GAA in vivo applications to reduce protein adsorption and cell adhesion, thereby improving its bioavailability and stability.
Reactivity: The C4 fatty amide bond enables mPEG-GAA to react with amino and peptide coupling agents such as NHS, DCC and EDC. This reactivity allows mPEG-GAA to be coupled or modified with other biomolecules (such as proteins, peptides, etc.), giving these biomolecules new functions and properties.
Versatility: Carboxyl group (COOH), as another important functional group of mPEG-GAA, has a variety of chemical reactivity. It can participate in many chemical reactions such as esterification and amidation, which further expands the application range of mPEG-GAA.
3. Application field
Drug delivery system: mPEG-GAA can be used as a carrier or modifier of drugs, coupling with drug molecules through its reactivity to improve drug stability and bioavailability. At the same time, the hydrophilicity of the PEG segment also helps to improve the solubility and dispersibility of the drug.
Biomedical applications: In the biomedical field, mPEG-GAA can be used to prepare biomaterials, biosensors, etc. Through the reactivity of its functional groups, mPEG-GAA can be coupled or modified with biomolecules, thereby conferring new functions and properties on these biomaterials.
Polymer material modification: mPEG-GAA can also be used as a polymer material modifier, through its functional group reactivity and polymer material copolymerization or crosslinking, thereby improving the stability and biocompatibility of the material.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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