Has been registered, DMF 037263
SINOPEG offers mPEG-MAL with molecular weight 2K, 5K, 10K, 20K and 40K Da, other M.W. may be available by custom synthesis. The packaging sizes are available for 1g, 10g and 100g.
Please contact us for bulk and GMP grade PEGs pricing and packaging size. MW 2000 Da, MW 5000 Da, MW 10000 Da, MW 20000 Da, MW 40000 Da are available.
SINOPEG is serving pharmaceutical and medical device companies around the globe, with product presence in various pharmaceutical/device development pipeline (pre-clinical, clinical, and post authorization large scale supply). Our facility is ISO9001 and ISO13485 certified, and is operating according to ICH Q7A guidelines to produce products for pharmaceutical companies.
Reference:
1. Pan LQ, Zhao WB, Lai J, et al. Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities. Sci Rep. 2015;5:14872. Published 2015 Oct 8. doi:10.1038/srep14872
2. Wan, Xue, Xue Wan, et al. Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins. Process Biochemistry 52 (2017): 183-191. doi:10.1016/j.procbio.2016.09.029
3. Wei X, Yang X, Zhao W, Xu Y, Pan L, Chen S. Optimizing Multistep Delivery of PEGylated Tumor-Necrosis-Factor-Related Apoptosis-Inducing Ligand-Toxin Conjugates for Improved Antitumor Activities. Bioconjug Chem. 2017;28(8):2180-2189. doi:10.1021/acs.bioconjchem.7b00327
4. Chung SF, Kim CF, Tam SY, et al. A bioengineered arginine-depleting enzyme as a long-lasting therapeutic agent against cancer. Appl Microbiol Biotechnol. 2020;104(9):3921-3934. doi:10.1007/s00253-020-10484-4
5. Pan LQ, Wang HB, Lai J, Xu YC, Zhang C, Chen SQ. Site-specific PEGylation of a mutated-cysteine residue and its effect on tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Biomaterials. 2013;34(36):9115-9123. doi:10.1016/j.biomaterials.2013.08.020
