4-arm PEG-SH

4-arm Poly(ethylene glycol) thiol

4-arm Poly(ethylene glycol) thiolmanufactured by SINOPEG is a high quality multi-arm PEG derivative with thiol groups at each terminal of the four arms connected to one pentaerythritol core. The reactive SH groups can be easily oxidized to form disulfide bonds. The total molecular weight of 4-arm PEGs is the sum of the molecular weight of all four arms.  4-arm PEG-SH is available with molecular weight of 2K, 5K, 10K, 20K and 40K Da. Other MW may be available by custom synthesis. The packaging sizes are available for 1g, 10g and 100g. Please contact us for bulk and GMP grade PEGs pricing and packaging size.

Xiamen Sinopeg Biotech Co., Ltd. is dedicated to drug delivery systems and related medical device business, focusing on the research, development, production and sales of high-end drug delivery carriers/auxiliary materials/APIs, medical materials, including but not limited to polyethylene glycol derivatives, lipid products, blood sugar control drug modifiers, block copolymers, ADC/ProTAC linkers, biodegradable polymers, exosomes, viral-like particles, as well as providing CDMO and solution services. These products are widely used in long-acting protein/peptide drugs, mRNA vaccines, small nucleic acid drugs, blood sugar control drugs, macromolecular micelle drugs, liposome drugs, gene therapy drugs, immunosuppressants, ADC drugs, ProTAC drugs, medical hydrogels, and other fields, placing the company in a leading position in the industry.

SINOPEG holds 40+ patents, with 80+ more pending, and 30+ products filed in DMF/CDE. The company has ISO 9001/ISO 13485/ISO 14001/ISO 45001 certification. The laboratory and production workshop are designed and built in accordance with the cGMP standard of FDA. We follow the requirements of ICH-Q7A to organize production at scale, to provide high quality drug delivery products and services to customers globally.

Our online catalog or inventory may not listed or have all molecular weights and functional groups, which may be available by custom synthesis. Please contact us at sales@sinopeg.com for quotation and availability.

Reference:

1. Lo YW, Sheu MT, Chiang WH, et al. In situ chemically crosslinked injectable hydrogels for the subcutaneous delivery of trastuzumab to treat breast cancer. Acta Biomater. 2019;86:280-290. doi:10.1016/j.actbio.2019.01.003
2. Chen Z, Cai Z, Zhu C, et al. Injectable and Self-Healing Hydrogel with Anti-Bacterial and Anti-Inflammatory Properties for Acute Bacterial Rhinosinusitis with Micro Invasive Treatment. Adv Healthc Mater. 2020;9(20):e2001032. doi:10.1002/adhm.202001032
3. Li D, Lv P, Fan L, et al. The immobilization of antibiotic-loaded polymeric coatings on osteoarticular Ti implants for the prevention of bone infections. Biomater Sci. 2017;5(11):2337-2346. doi:10.1039/c7bm00693d
4. Yang WJ, Xu W, Tao X, et al. Two-stage thiol-based click reactions for the preparation and adhesion of hydrogels. Polymer Chemistry. 2020;11(17):2986-2994. dio:10.1039/c9py01503e
5. Wang N, Chen J, Chen Y, et al. Kneadable Dough-type hydrogel transforming from dynamic to rigid network to repair irregular bone Defects [J]. Bioactive Materials, 2024, 40: 430–444.
6. Si, J., Ishikawa, S., Nepal, S. et al. Osteogenic differentiation capabilities of multiarm PEG hydrogels: involvement of gel–gel-phase separation in cell differentiation. Polym J 57, 407–417 (2025). https://doi.org/10.1038/s41428-024-00955-0
7. Cho, R., Kamata, H., Tsuji, Y. et al. Optimizing a self-solidifying hydrogel as an endoscopically deliverable hydrogel coating system: a proof-of-concept study on porcine endoscopic submucosal dissection-induced ulcers. Polym J 56, 855–863 (2024). https://doi.org/10.1038/s41428-024-00921-w
8. Winkelbauer M, Hasenauer A, Rütsche D, et al. Rapid Deep Vat Printing Using Photoclickable Collagen-Based Bioresins. Adv Healthc Mater. Published online July 4, 2025. doi:10.1002/adhm.202405105
9. Nepal S, Si J, Ishikawa S, et al. Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects. Regen Ther. 2023;25:24-34. Published 2023 Nov 25. doi:10.1016/j.reth.2023.11.008
10. Zhou C, Sun M, Wang D, et al. In Vitro Antibacterial and Anti-Inflammatory Properties of Imidazolium Poly(ionic liquids) Microspheres Loaded in GelMA-PEG Hydrogels. Gels. 2024;10(4):278. Published 2024 Apr 20. doi:10.3390/gels10040278
11. Xu Z, Lu J, Lu D, et al. Rapidly damping hydrogels engineered through molecular friction. Nat Commun. 2024;15(1):4895. Published 2024 Jun 8. doi:10.1038/s41467-024-49239-4
12. Ishikawa S, Kamata H, Sakai T. Enhancing cell adhesion in synthetic hydrogels via physical confinement of peptide-functionalized polymer clusters. J Mater Chem B. 2024;12(29):7103-7112. Published 2024 Jul 24. doi:10.1039/d4tb00761a
13. Wang N, Chen J, Chen Y, et al. Kneadable Dough-type hydrogel transforming from dynamic to rigid network to repair irregular bone Defects [J]. Bioactive Materials, 2024, 40: 430–444.
14. Si, J., Ishikawa, S., Nepal, S. et al. Osteogenic differentiation capabilities of multiarm PEG hydrogels: involvement of gel–gel-phase separation in cell differentiation. Polym J 57, 407–417 (2025). https://doi.org/10.1038/s41428-024-00955-0
15. Cho, R., Kamata, H., Tsuji, Y. et al. Optimizing a self-solidifying hydrogel as an endoscopically deliverable hydrogel coating system: a proof-of-concept study on porcine endoscopic submucosal dissection-induced ulcers. Polym J 56, 855–863 (2024). https://doi.org/10.1038/s41428-024-00921-w
16. Winkelbauer M, Hasenauer A, Rütsche D, et al. Rapid Deep Vat Printing Using Photoclickable Collagen-Based Bioresins. Adv Healthc Mater. Published online July 4, 2025. doi:10.1002/adhm.202405105
17. Nepal S, Si J, Ishikawa S, et al. Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects. Regen Ther. 2023;25:24-34. Published 2023 Nov 25. doi:10.1016/j.reth.2023.11.008
18. Zhou C, Sun M, Wang D, et al. In Vitro Antibacterial and Anti-Inflammatory Properties of Imidazolium Poly(ionic liquids) Microspheres Loaded in GelMA-PEG Hydrogels. Gels. 2024;10(4):278. Published 2024 Apr 20. doi:10.3390/gels10040278
19. Xu Z, Lu J, Lu D, et al. Rapidly damping hydrogels engineered through molecular friction. Nat Commun. 2024;15(1):4895. Published 2024 Jun 8. doi:10.1038/s41467-024-49239-4
20. Ishikawa S, Kamata H, Sakai T. Enhancing cell adhesion in synthetic hydrogels via physical confinement of peptide-functionalized polymer clusters. J Mater Chem B. 2024;12(29):7103-7112. Published 2024 Jul 24. doi:10.1039/d4tb00761a