8-arm Poly(ethylene glycol) vinylsulfone(TP)
|
Number |
Mn |
|
06020905002 |
2,000 |
|
06020905006 |
5,000 |
|
06020905009 |
10,000 |
|
06020905012 |
20,000 |
|
06020905015 |
40,000 |
8-arm PEG vinylsulfone (tripentaerythritol) is synthesized through ethoxylation of tripentaerythritol. It is a multifunctional PEG reagent with 8 thiol reactive vinylsulfone groups. VS selectively reacts with free thiol, sulfhydryl or mercapto groups for site specific pegylation of peptide and proteins. 8ARM(TP)-PEG with tripentaerythritol core has a higher purity and lower polydispersity compared with the generic 8ARM-PEG with a hexaglycerin core. The total molecular weight of 8-arm PEGs is the sum of the molecular weight of all eight arms.
8-arm PEG-VS (TP) is available with molecular weight of 2K, 5K, 10K, 20K and 40K Da. Other MW may be available by custom synthesis. The packaging sizes are available for 1g, 10g and 100g. Please contact us for bulk and GMP grade PEGs pricing and packaging size.
Xiamen Sinopeg Biotech Co., Ltd. is dedicated to drug delivery systems and related medical device business, focusing on the research, development, production and sales of high-end drug delivery carriers/auxiliary materials/APIs, medical materials, including but not limited to polyethylene glycol derivatives, lipid products, blood sugar control drug modifiers, block copolymers, ADC/ProTAC linkers, biodegradable polymers, exosomes, viral-like particles, as well as providing CDMO and solution services. These products are widely used in long-acting protein/peptide drugs, mRNA vaccines, small nucleic acid drugs, blood sugar control drugs, macromolecular micelle drugs, liposome drugs, gene therapy drugs, immunosuppressants, ADC drugs, ProTAC drugs, medical hydrogels, and other fields, placing the company in a leading position in the industry.
SINOPEG holds 40+ patents, with 80+ more pending, and 30+ products filed in DMF/CDE. The company has ISO 9001/ISO 13485/ISO 14001/ISO 45001 certification. The laboratory and production workshop are designed and built in accordance with the cGMP standard of FDA. We follow the requirements of ICH-Q7A to organize production at scale, to provide high quality drug delivery products and services to customers globally.
Our online catalog or inventory may not listed or have all molecular weights and functional groups, which may be available by custom synthesis. Please contact us at sales@sinopeg.com for quotation and availability.
References:
1. Below, C.R., et al., A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids. Nature materials, 2022, 21(1).
2. Nason-Tomaszewski, C. E., et al., Extracellular matrix-templating fibrous hydrogels promote ovarian tissue remodeling and oocyte growth, Bioactive Materials, 32, 2024, P. 292-303.
3. Day, J.R., et al., The impact of functional groups of poly(ethylene glycol) macromers on the physical properties of photo-polymerized hydrogels and the local inflammatory response in the host, Acta Biomaterialia, 2018, 67, P. 42-52.
4. Gnecco, J.S., et al., Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk, Med, 4(8), 2023.
5. Tomaszewski, C. E., et al., Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation, Acta Biomaterialia, 2021.
