I. Basic Information

Name: 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine

CAS Number: 923-61-5

Appearance: White powder

Storage Conditions: Store sealed, protected from light, below -20°C.

II. Structural Features

Chemical Structure: Composed of two palmitoyl chains (C16:0) linked via ester bonds to an sn-glycero-3-phosphoethanolamine backbone.

Amphiphilicity: Possesses both hydrophilic (phosphoethanolamine head group) and hydrophobic (palmitoyl tails) properties, making it a key material for liposome formation.

Modifiability: Can be modified via PEGylation (e.g., mPEG-DPPE) to improve liposome stability and circulation time in the bloodstream.

III. Major Applications

Drug Delivery

Serves as a liposome membrane material for encapsulating anticancer drugs, gene therapies, etc., enhancing targeting and sustained release.

PEG-DPPE derivatives can prolong the half-life of liposomes in the blood.

Biological Research

Used to model cell membrane structures and study membrane protein function.

Used in transfection reagents to facilitate nucleic acid entry into cells.

Industrial Applications

Coordinates with transition metals (e.g., palladium, rhodium) to catalyze organic synthesis reactions.