1. Basic structure of mPEG-SCM
Mpeg-scm consists of methoxy polyethylene glycol (mPEG) and succinimide (SCM). Among them, mPEG provides hydrophobic shielding and hydrophilicity, enhances solubility and reduces non-specific protein adsorption; SCM is an active ester group that reacts with an amine group to form a stable amide bond.
2. Introduction of functional groups
Methoxy terminal group (mPEG portion) :
One end is a methoxy group, and the sealing end provides stability.
Gives mPEG-SCM good water solubility and biocompatibility.
Succinimide (SCM part) :
The other end contains the active ester, the succinimide group.
The group has a five-membered ring structure with double bonds and is chemically very active.
It can be quickly coupled with amino groups (such as lysine side chains) in proteins, antibodies, peptides and other molecules to form stable amide bonds.
In pH 7~9 buffering systems, SCM reacts with amines efficiently and under mild reaction conditions, which is suitable for labeling or coupling of biomolecules.
3. Application of mPEG-SCM
Protein modification: Used to PEG proteins and antibodies to improve molecular stability and extend their half-life in the body.
Surface functionalization of nanomaterials: Modify the surface of nanoparticles (such as liposomes, gold nanoparticles) to improve their solubility and distribution in vivo.
Drug delivery vector preparation: In drug delivery systems, mPEG-SCM can be used to encapsulate and release drugs to improve drug stability and bioavailability.
Biological imaging: Combined with fluorescent dyes, magnetic resonance imaging agents and other markers, to prepare a variety of biological imaging reagents, for cells, tissues, animals and other different levels of imaging.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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