1. Basic information
Molecular form. The common methyl-PEG4-NHS ester is shown as C₁₄H₂₅NO₇.
Appearance: Generally white to white solid or powder.
Molecular weight: common 2kDa, 3.5kDa, 5kDa, 10kDa, 20kDa, 40kDa and so on.
2. Major functional groups
Methoxy (-OCH₃) : located at one end of the molecule, has a certain hydrophobicity, which can give mPEG-SPA a certain degree of fat solubility, so that it has a good solubility in some organic solvents, and also plays a role in protecting the end of the polyethylene glycol chain to prevent unnecessary side reactions during the reaction.
Succinimide (NHS ester) : is a very important active functional group in mPEG-SPA. It has high reactivity and can react with primary amine (-NH₂) to form a stable amide bond under neutral or weakly alkaline conditions. Using this property, mPEG-SPA can be easily coupled with biological molecules containing primary amine groups, such as proteins, peptides, antibodies, etc., so that it has a wide range of applications in the biomedical field, such as the preparation of PEG-based drugs, modifying biosensors.
Polyethylene glycol (PEG) chain: Although the PEG chain is not a functional group in the traditional sense, it can be regarded as a structural unit with special properties. PEG chain has good biocompatibility, water solubility and flexibility, which can increase the water solubility of connected molecules, reduce immunogenicity, and extend the circulation time of molecules in the body.
3. Application field
Biomedical field: Used for protein modification, improve protein stability, etc. Drug coupling can be performed to prolong the circulation time of drugs in the body; It can also build biosensors for target molecular detection.
Materials science: can modify the surface of materials, improve biocompatibility and anti-fouling performance; It can also be used to modify the surface of nanoparticles to improve stability and dispersion.
Product technical advantage
SINOPEG offers high quality PEG derivatives with novel and diverse product structures, abundant substituting groups, and high end-group substitution rates.
High PEG functional group content - Content up to 99%
Functionalization of PEG is the most difficult of PEG products. The common problem of the main products on the market is that the functional group content is not high. And we master the modification technology, initiation system, unconventional precipitation method and system extraction method and other technologies and processes can easily produce high functional group content products. The functional group content of most products can reach 99%, which is much higher than the 90% or so of rivals.
High quality PEG molecular weight control -PDI <1.05
The single molecule chain of a polymer is usually composed of many small repeating units connected by polymerization. The design and control of the synthesis method has a crucial influence on the length of a single polymer segment and the similarity of the length of multiple polymer segments. Our PEG synthesis technology guarantees very good dispersion (PDI<1.05), while many other companies' products typically have PDI around 1.1.
Relevant recommendation
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mPEG-NH2
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3-arm PEG-OH
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mPEG-CM
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3-arm PEG-NH2
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mPEG-SA
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3-arm PEG-CM
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mPEG-SH
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3-arm PEG-SH
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mPEG-pALD
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3-arm PEG-SC
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mPEG-MAL
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3-arm PEG-N3
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mPEG-SC
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3-arm PEG-NH2·HCl
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mPEG-NPC
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4-arm PEG-OH
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mPEG-SS
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4-arm PEG-NH2
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mPEG-N3
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4-arm PEG-CM
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mPEG-AA
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4-arm PEG-SA
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mPEG-MA
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4-arm PEG-SH
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mPEG-VS
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6-arm PEG-OH
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mPEG-NH2·HCl
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6-arm PEG-NH2
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2-arm PEG-OH
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6-arm PEG-CM
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2-arm PEG-COOH
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6-arm PEG-SA
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2-arm PEG-NHS
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6-arm PEG-SH
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2-arm PEG-MAL
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8-arm PEG-NH2
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2-arm PEG-NH2
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8-arm PEG-CM
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2-arm PEG-Acetal
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8-arm PEG-SA
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2-arm PEG-CHO
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8-arm PEG-SH
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2-arm PEG-N3
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8-arm PEG-pALD
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