| Name | Mn | Product ID |
| GalNAc-PEG-DTA-5 | 2,000 | 06020329802 |
GalNAc-PEG-DTA-5-2Kis a liver-targeting functional PEG lipid specifically engineered for LNP formulations, comprising three synergistic components:
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GalNAc Targeting Head
Designed with a GalNAc targeting moiety, it achieves active hepatocyte targeting through high-affinity binding to the asialoglycoprotein receptor (ASGPR), which is abundantly expressed on the surface of liver parenchymal cells. This design represents one of the most well-established liver-targeting strategies in the field and has been extensively validated in numerous published studies and clinical pipelines. -
PEG Spacer Arm
Providing an approximately 2 kDa long-chain PEG hydrophilic shielding layer, it fully exposes the targeting head on the LNP surface, allowing for conformational freedom and efficient receptor binding. Concurrently, it effectively prolongs the systemic circulation time of LNPs and minimizes non-specific protein adsorption. -
DTA-5 Hydrophobic Anchor
A lipophilic anchoring structure specifically developed by Sinopeg for the LNP bilayer environment. It is designed to optimize the anchoring stability of the PEG lipid on the particle surface, thereby supporting the structural integrity of lipid nanoparticles during circulation.
