LNP formulations usually have between 35-45% composition with respect to cholesterol.

Cholesterol is a derivative of cyclopentane polyhydrophenanthrene, which is widely present in animals. Cholesterol is involved in the formation of cell membranes and is an indispensable and important substance in animal tissue cells.

Traditionally, cholesterol is derived from animals, mainly from the saponification of the brain and vertebral tendons of pigs, cattle and sheep, or lanolin, which is extracted using organic solvents.

Since many diseases are now found to be transmitted from animals to humans, according to the latest guidelines for cell therapy and gene therapy, animal-derived ingredients should be avoided and a safer source of cholesterol is needed.

SINOPEG's plant-derived cholesterol is synthesized through biosynthesis technology using plant extracts as the initial raw material. The product has no animal origin and meets the guidelines for cell therapy and gene therapy with high safety and clear composition.

The product is a pure plant-derived biosynthetic cholesterol with no animal-derived components. It is less risky compared to traditional lanolin, pig, and cow products of animal origin.

Plant-derived cholesterol is well suited for applications in the preparation of lipid nanoparticle (LNP) delivery systems, in the development of mRNA vaccines, in cell culture, serum-free cell culture for protein drugs, and other high-technology drug researches.

Plant-derived cholesterol can also be used as a key raw material for the synthesis of vitamin D and its derivatives.

The typical application includes such as in small unilamellar vesicles’ preparation, in the preparation of small unilamellar vesicles for structured illumination microscopy studies, in the generation of thymoquinone (TQ) loaded liposomes for administering into murine model with Candida albicans infection.

Lipids for LNPs

US Tel: 1-844-782-5734

US Tel: 1-844-QUAL-PEG

CHN Tel: 400-918-9898

Email: sales@sinopeg.com