Int J Nanomedicine. 2015 Aug 20:10:5219-35. doi: 10.2147/IJN.S82847. eCollection 2015. D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery Yupei Wu, Qian Chu, Songwei Tan, Xiangting Zhuang, Yuling Bao, Tingting Wu, Zhiping Zhang Abstract Paclitaxel (PTX) is one of the most effective antineoplastic drugs. Its current clinical administration Taxol(®) is formulated in Cremophor EL, which causes serious side effects. Nanoparticles (NP) with lower systemic toxicity and enhanced therapeutic efficiency may be an alternative formulation of the Cremophor EL-based vehicle for PTX delivery. In this study, novel amphipathic 4-arm-PEG-TPGS derivatives, the conjugation of D-α-tocopherol polyethylene glycol succinate (TPGS) and 4-arm-polyethylene glycol (4-arm-PEG) with different molecular weights, have been successfully synthesized and used as carriers for the delivery of PTX. These 4-arm-PEG-TPGS derivatives were able to self-assemble to form uniform NP with PTX encapsulation. Among them, 4-arm-PEG(5K)-TPGS NP exhibited the smallest particle size, highest drug-loading efficiency, negligible hemolysis rate, and high physiologic stability. Therefore, it was chosen for further in vitro and in vivo investigations. Facilitated by the effective uptake of the NP, the PTX-loaded 4-arm-PEG(5K)-TPGS NP showed greater cytotoxicity compared with free PTX against human ovarian cancer (A2780), non-small cell lung cancer (A549), and breast adenocarcinoma cancer (MCF-7) cells, as well as a higher apoptotic rate and a more significant cell cycle arrest effect at the G2/M phase in A2780 cells. More importantly, PTX-loaded 4-arm-PEG(5K)-TPGS NP resulted in a significantly improved tumor growth inhibitory effect in comparison to Taxol(®) in S180 sarcoma-bearing mice models. This study suggested that 4-arm-PEG(5K)-TPGS NP may have the potential as an anticancer drug delivery system. Keywords: 4-arm-PEG; TPGS; antitumor; nanoparticles; paclitaxel. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

We are delighted to invite you to the prestigious CPHI CHINA, where SINOPEG will be showcasing our latest innovations and products. The event will be held at the Shanghai New International Expo Center from June 19th to 21st, 2024. CPHI CHINA is a leading platform for the pharmaceutical industry, bringing together top professionals, suppliers, and manufacturers from around the world. At our booth W4G31, you will have the opportunity to witness firsthand the cutting-edge solutions and advancements that SINOPEG has to offer. Our dedicated team will be available to provide detailed information, answer any queries, and discuss potential partnerships. We cordially invite you to join us at the SINOPEG booth W4G31 at CPHI CHINA and be part of this exciting event. Your presence and engagement will contribute significantly to the success of the exhibition. We look forward to meeting you and exploring potential synergies. Please feel free to contact us if you require any further information or to schedule a meeting during the event. We can be reached at sales@sinopeg.com. Thank you for considering our invitation. We eagerly anticipate your positive response and the opportunity to connect at CPHI CHINA.

The Dragon Boat Festival, also known as Duanwu Festival, is a traditional Chinese holiday that has a history of over 2,000 years. It is celebrated on the 5th day of the 5th month of the lunar calendar, which usually falls in June on the Gregorian calendar. This festival is widely observed in many Chinese communities around the world. One of the most prominent features of the Dragon Boat Festival is the thrilling dragon boat races. Teams of rowers paddle vigorously to the beat of drums, racing their elaborately decorated boats on rivers and lakes. These races are not only a thrilling sport but also a way to commemorate the popular Chinese poet Qu Yuan. Qu Yuan was a highly respected poet and politician who lived during the Warring States period in ancient China. He was known for his love for his country and his relentless fight against corruption. When his kingdom was invaded and conquered, Qu Yuan drowned himself in the Miluo River in despair. To prevent fish from devouring his body, people raced their boats on the river, splashed water, and threw Zongzi, a traditional sticky rice dumpling, into the water as offerings. Zongzi is a special food associated with the Dragon Boat Festival. It is made by wrapping glutinous rice, with a variety of fillings such as meat, beans, or nuts, in bamboo leaves and then steaming or boiling them. These delicious treats symbolize the rice that was thrown into the river to feed the fish and divert their attention away from Qu Yuan's body. Besides dragon boat races and Zongzi, the Dragon Boat Festival also features other customs and traditions. People often hang up pouches of herbal medicines, called "zhongzi," and mugwort leaves on their doors to ward off evil spirits and diseases. Additionally, children wear colorful silk threads to protect themselves from evil spirits and bring good luck. In recent years, the Dragon Boat Festival has gained popularity beyond Chinese communities. Many countries have embraced this festive occasion and organized dragon boat races to celebrate multic.

Welcome to visit SINOPEG at booth no.911. Each year, the TIDES conference scientific agenda includes 150+ of the industry's top scientists to present the latest science and industry updates across the entire spectrum from discovery, preclinical, clinical development through CMC, Manufacturing and commercialization of therapeutics and vaccines for oligos, peptides, mRNA and genome editing products. The TIDES USA program features concurrent tracks covering the following 6 scientific themes including in-depth development strategies, trends, and technologies across the entire spectrum of oligonucleotides, peptides, mRNA, and genome editing.

Nanoscale. 2015 Mar 12;7(12):5249-61. doi: 10.1039/c4nr07591a. Core-shell hybrid upconversion nanoparticles carrying stable nitroxide radicals as potential multifunctional nanoprobes for upconversion luminescence and magnetic resonance dual-modality imaging Chuan Chen 1, Ning Kang, Ting Xu, Dong Wang, Lei Ren, Xiangqun Guo Abstract Nitroxide radicals, such as 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) and its derivatives, have recently been used as contrast agents for magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI). However, their rapid one-electron bioreduction to diamagnetic N-hydroxy species when administered intravenously has limited their use in in vivo applications. In this article, a new approach of silica coating for carrying stable radicals was proposed. A 4-carboxyl-TEMPO nitroxide radical was covalently linked with 3-aminopropyl-trimethoxysilane to produce a silanizing TEMPO radical. Utilizing a facile reaction based on the copolymerization of silanizing TEMPO radicals with tetraethyl orthosilicate in reverse microemulsion, a TEMPO radicals doped SiO2 nanostructure was synthesized and coated on the surface of NaYF4:Yb,Er/NaYF4 upconversion nanoparticles (UCNPs) to generate a novel multifunctional nanoprobe, PEGylated UCNP@TEMPO@SiO2 for upconversion luminescence (UCL) and magnetic resonance dual-modality imaging. The electron spin resonance (ESR) signals generated by the TEMPO@SiO2 show an enhanced reduction resistance property for a period of time of up to 1 h, even in the presence of 5 mM ascorbic acid. The longitudinal relaxivity of PEGylated UCNPs@TEMPO@SiO2 nanocomposites is about 10 times stronger than that for free TEMPO radicals. The core-shell NaYF4:Yb,Er/NaYF4 UCNPs synthesized by this modified user-friendly one-pot solvothermal strategy show a significant enhancement of UCL emission of up to 60 times more than the core NaYF4:Yb,Er. Furthermore, the PEGylated UCNP@TEMPO@SiO2 nanocomposites were further used as multifunctional nanoprobes to explore their performance in the UCL imaging of living cells and T1-weighted MRI in vitro and in vivo. Related products Abbreviation: mPEG-NHS For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2017 Jan 25;9(3):2205-2212.  doi: 10.1021/acsami.6b15364.  Epub 2017 Jan 10. Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility Yazhong Bu 1 2, Hong Shen 1, Fei Yang 1 2, Yanyu Yang 1 2, Xing Wang 1, Decheng Wu 1 2 Abstract Hydrogels are required to have high mechanical properties, biocompatibility, and an easy fabrication process for biomedical applications.  Double-network hydrogels, although strong, are limited because of the complicated preparation steps and toxic materials involved.  In this study, we report a simple method to prepare tough, in situ forming polyethylene glycol (PEG)-agarose double-network (PEG-agarose DN) hydrogels with good biocompatibility.  The hydrogels display excellent mechanical strength.  Because of the easily in situ forming method, the resulting hydrogels can be molded into any form as needed.  In vitro and in vivo experiments illustrate that the hydrogels exhibit satisfactory biocompatibility, and cells can attach and spread on the hydrogels.  Furthermore, the residual amino groups in the network can also be functionalized for various biomedical applications in tissue engineering and cell research. Keywords: PEG;  agarose;  biocompatible;  double network;  hydrogels. Related products Abbreviation: 4-arm-PEG-NHS Abbreviation: 4-arm-PEG-NH2 For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Colloids Surf B Biointerfaces. 2018 May 1:165:144-149. doi: 10.1016/j.colsurfb.2018.02.032. Epub 2018 Feb 15. Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release Juan Wang 1, Geoffrey S Williamson 2, Hu Yang 3 Abstract In this work, we developed a new class of branched polyrotaxane hydrogel made of 4-arm polyethylene glycol (4-PEG) and α-cyclodextrin (α-CD) using supramolecular host-guest interactions as a cross-linking strategy. Because of the dynamic nature of the non-covalent host-guest cross-linking, the resulting supramolecular α-CD/4-PEG hydrogels show thixotropic behavior and undergo a reversible gel-sol transition in response to shear stress change. We loaded the antiglaucoma drug brimonidine into the α-CD/4-PEG gel and found the drug release kinetics was controlled by shear stress. This thixotropic shear thinning property makes the supramolecular hydrogels highly attractive in drug delivery applications and suitable for preparation of injectable drug formulations. Keywords: Branched PEG; Glaucoma; Host-guest interaction; Supramolecular; Thixotropic. Related products Abbreviation: 4-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Biomaterials. 2019 Feb:192:392-404.   doi: 10.1016/j.biomaterials.2018.10.047.   Epub 2018 Nov 2. A PEG-Lysozyme hydrogel harvests multiple functions as a fit-to-shape tissue sealant for internal-use of body Haoqi Tan 1, Dawei Jin 2, Xue Qu 3, Huan Liu 1, Xin Chen 1, Meng Yin 4, Changsheng Liu 5 Abstract In situ formation of surgical sealants to stop internal fluids leakage is more attractive compared to the traditional suture or staple.   However, commercial sealants have weak points in tissue adhesive, cell affinity, antibacterial etc., which make them remain suboptimal for internal use of body.   It is required to develop multifunctional sealants that can meet clinical needs.   Herein, a PEG-lysozyme (LZM) injectable sealant composed of 4-arm-PEG and lysozyme was developed.   Lysozyme offers free amine groups to rapidly cross link with PEG.   The hydrogel can tightly adhere to tissues and provide good mechanics to withstand high pressure.   Moreover, lysozyme innately confers antibacterial and cell affinity on the hydrogel that are usually lacking in marketed sealants.   The hydrogel is easily operated to seal gas or blood leakage in a rabbit trachea and artery defect.   Moreover, it can close the transmural left ventricular wall defect on a beating heart.   The traumatic organ functions completely recovered postoperatively.   Considering the good biocompatibility and the simple fabrication process, the PEG-LZM hydrogel is promising to clinical transformation.   More broadly, our work indicates that nature-occurring molecules are versatile building blocks for construction of materials and confer functions, which represents a simple tragedy to develop advanced functional biomaterials. Keywords: 4-Arm-Poly ethylene glycol;   Antimicrobial;   Cell attachment;   Injectable hydrogel;   Lysozyme;   Tissue sealing. Related products Abbreviation: 4-arm-PEG-NHS For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com