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  • SINOPEG achieved so much in CPhI China 2019
    SINOPEG achieved so much in CPhI China 2019 2019-06-23
    CPhI China 2019 was held successfully in Shanghai, China from June 18th-20th. We Sinopeg sent a very professional sales team to participate this exhibition. Our booth Number is W4F21. During the exhibition, we had very deep disscuion with old partner, and customers from all over the world came to  consult the company's products,we obtained the approval and praise from our customers. Looking forward to see you again next year, CPhI China 2020 in Shanghai.
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  • SINOPEG were certified ISO 13485 system qualification in August 2015.
  • SINOPEG were certified ISO-9001 quality management system qualification in November 2014.
  • SINOPEG exhibits at 2019 API China (May 8 - May 10,2019)
    SINOPEG exhibits at 2019 API China (May 8 - May 10,2019) 2019-03-03
    Warmly welcome you to visit our booth 1D73 in API  (Hangzhou) from May. 8th to May. 10th, 2019. Exhibition name: the 82nd API China- China international pharmaceutical raw materials, intermediates, packaging, equipment fair. Booth number:1D73 Time: May 8-10,2019 Venue: Hangzhou international expo center We provided a wealth of polyethylene glycol derivatives, side chains of hypoglycemic drugs (Semaglutide side chain, Liraglutide side chain, Insulin Detemir side chain, Insulin Deglutide chain), polyethylene glycol block copolymers, polyethylene glycol phospholipids, etc. Welcome to our booth.
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  • Visit SINOPEG at 2019 CPhI Worldwide, Germany
  • Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging
    Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging January 18,2024.
    Research Article | Issue | Published: 06 December 2016 Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging Mei Chen1,§, Shuzhen Chen2,3,§, Chengyong He2,§, Shiguang Mo1, Xiaoyong Wang2, Gang Liu2, Nanfeng Zheng1 Abstract Two-dimensional (2D) nanosheets have emerged as an important class of nanomaterial with great potential in the field of biomedicines, particularly in cancer theranostics.   However, owing to the lack of effective methods that synthesize uniform 2D nanomaterials with controlled size, systematic evaluation of size-dependent bio-behaviors of 2D nanomaterials is rarely reported.   To the best of our knowledge, we are the first to report a systematic evaluation of the influence of size of 2D nanomaterials on their bio-behaviors.   2D Pd nanosheets with diameters ranging from 5 to 80 nm were synthesized and tested in cell and animal models to assess their size-dependent bioapplication, biodistribution, elimination, toxicity, and genomic gene expression profiles.   Our results showed size significantly influences the biological behaviors of Pd nanosheets, including their photothermal and photoacoustic effects, pharmacokinetics, and toxicity.   Compared to larger-sized Pd nanosheets, smaller-sized Pd nanosheets exhibited more advanced photoacoustic imaging and photothermal effects upon ultralow laser irradiation.   Moreover, in vivo results indicated that 5-nm Pd nanosheets escape from the reticuloendothelial system with a longer blood half-life and can be cleared by renal excretion, while Pd nanosheets with larger sizes mainly accumulate in the liver and spleen.   The 30-nm Pd nanosheets exhibited the highest tumor accumulation.   Although Pd nanosheets did not cause any appreciable toxicity at the cellular level, we observed slight lipid accumulation in the liver and inflammation in the spleen.   Genomic gene expression analysis showed that 80-nm Pd nanosheets interacted with more cellular components and affected more biological processes in the liver, as compared to 5-nm Pd nanosheets.   We believe this work will provide valuable information and insights into the clinical application of 2D Pd nanosheets as nanomedicines. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • Visit SINOPEG at TIDES USA
    Visit SINOPEG at TIDES USA April 12,2024.
    We are delighted to invite you to visit our booth at TIDES USA, taking place from May 14th to 17th, 2024 in Boston, USA. The exhibition booth number for SINOPEG is 911. TIDES USA serves as an excellent platform for networking, sharing knowledge, and exploring cutting-edge innovations. At our booth #911, you can expect an engaging and informative experience. We have prepared a wide range of exciting content to share with you, including ADC/PROTAC PEG Linkers, GLP-1 Intermediates, Block Copolymers, etc. We believe these offerings will spark interesting discussions and provide valuable insights into the latest developments in the industry. Whether you are looking to collaborate, explore potential partnerships, or simply exchange ideas, our team will be available at booth 911 to meet and discuss further. We kindly request that you mark your calendar and reserve some time to visit our booth during the exhibition. We value your presence and look forward to the opportunity to connect with you. Should you have any inquiries or require further information, please do not hesitate to contact us. Thank you for considering our invitation, and we hope to see you at TIDES USA. For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • Engineering PEG-based hydrogels to foster efficient endothelial network formation in free-swelling and confined microenvironments
    Engineering PEG-based hydrogels to foster efficient endothelial network formation in free-swelling and confined microenvironments June 8,2020.
    Engineering PEG-based hydrogels can efficiently foster endothelial network formation in free-swelling and confined microenvironments Polyethylene glycol (PEG) and its derivatives are among the few polymers approved by the US FDA that can be used in biomedical products. The PEGl-based hydrogel has excellent flexibility and biocompatibility. Some PEG hydrogels can not only be degraded, but also can form bioactive site through modifying the connexins in a chemical way. In vitro tissue engineered models are expected to have significant impact on disease modeling and preclinical drug development. Reliable methods to induce microvascular networks in such microphysiological systems are needed to improve the size and physiological function of these models. By systematically engineering several physical and biomolecular properties of the cellular microenvironment (including crosslinking density, polymer density, adhesion ligand concentration, and degradability), the author Alexander Brown establish design principles that describe how synthetic matrix properties influence vascular morphogenesis in modular and tunable hydrogels based on commercial 8-arm poly (ethylene glycol) (PEG8a) macromers. The author applies these design principles to generate endothelial networks that exhibit consistent morphology throughout depths of hydrogel greater than 1 mm. These PEG8a-based hydrogels have relatively high volumetric swelling ratios (>1.5), which limits their utility in confined environments such as microfluidic devices. To overcome this limitation, the author mitigates swelling by incorporating a highly functional PEG-grafted alpha-helical poly (propargyl-l-glutamate) (PPLGgPEG) macromer along with the canonical 8-arm PEG8a macromer in gel formation. This hydrogel platform supports enhanced endothelial morphogenesis in neutral-swelling environments. Finally, the author incorporates PEG8a-PPLGgPEG gels into microfluidic devices and demonstrates improved diffusion kinetics and microvascular network formation in situ compared to PEG8a-based gels. [1] Brown A ,  He H ,  Trumper E , et al. Engineering PEG-based hydrogels to foster efficient endothelial network formation in free-swelling and confined microenvironments[J]. Biomaterials, 2020, 243:119921. If there is any copyright infringement, please contact us and we will remove the content at the first time. Sinopeg provide various NW poly(ethylene glycol) (PEG) products: 2KDa, 5KDa, 10KDa, 20KDa, etc. Products: Linear Monofunctional PEGs Linear Bifunctional PEGs Linear Heterofunctional PEGs Branched PEGs Multi-Arm Functional PEGs Functionally Grafted PEGs
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