Nat Commun.  2020 Mar 18;11(1):1435.   doi: 10.1038/s41467-020-14887-9. Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma Bin Kong, Yun Chen, Rui Liu, Xi Liu, Changyong Liu, Zengwu Shao, Liming Xiong, Xianning Liu, Wei Sun, Shengli Mi Abstract Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation.   In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold and infuse the scaffold with gelatin methacrylate (GelMA) hydrogel to obtain a 3 D fiber hydrogel construct;   the fiber spacing is adjusted to fabricate optimal construct that simulates the stromal structure with properties most similar to the native cornea.   The topological structure (3 D fiber hydrogel, 3 D GelMA hydrogel, and 2 D culture dish) and chemical factors (serum, ascorbic acid, insulin, and β-FGF) are examined to study their effects on the differentiation of limbal stromal stem cells to keratocytes or fibroblasts and the phenotype maintenance, in vitro and in vivo tissue regeneration.   The results demonstrate that fiber hydrogel and serum-free media synergize to provide an optimal environment for the maintenance of keratocyte phenotype and the regeneration of damaged corneal stroma. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

DOI https://doi.org/10.1039/C4TA05736H Citation J. Mater.    Chem.    A, 2015,3, 1158-1163 Facile functionalization of a tetrahedron-like PEG macromonomer-based fluorescent hydrogel with high strength and its heavy metal ion detection Abstract A tetrahedron-like PEG macromonomer-based fluorescent hydrogel was fabricated by a facile method.    The functional hydrogel shows comparable high strength, up to megapascals, and sensitivity to heavy metal ions, such as Cu2+, Zn2+, Pb2+, Co2+, Hg2+ and Ni2+, which allow a potentially rapid visual response, trace analysis and one-step recyclable sensing for metal ion detection. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Chemical Engineering Journal Volume 413, 1 June 2021, 127429 https://doi.org/10.1016/j.cej.2020.127429 Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing Abstract The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal4PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels. In vitro assays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities against Escherichia coli and Staphylococcus aureus due to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. The in vivo anti-infection results further demonstrated that the semi-IPN hydrogels could kill S. aureus and accelerate the healing of infected wounds. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Cite this: Langmuir 2015, 31, 51, 13834–13841 Publication Date:December 3, 2015 https://doi.org/10.1021/acs.langmuir.5b03823 Effect of Topological Structures on the Self-Assembly Behavior of Supramolecular Amphiphiles Juan Wang, Xing Wang, Fei Yang, Hong Shen, Yezi You, and Decheng Wu Abstract Three types of azobenzene-based telechelic guest polymers, PEG-azo, azo-PEG-azo, and PEG-azo4, were synthesized by a facile method.  Subsequently, a series supramolecular amphiphiles with three distinct topological structures (hemitelechelic, ditelechelic, and quadritelechelic) were constructed through coupling with host polymer β-cyclodextrin-poly(l-lactide) (β-CD-PLLA) by combined host–guest complexation.  Research on the self-assembly behavior of these amphiphiles demonstrated that the variation in self-assembly was tuned by the synergistic interaction of hydrophilicity and the curvature of the polymer chains, and very importantly, the topological structure of amphiphiles demonstrated effective control of the self-assembly behavior. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Int J Nanomedicine. 2015 Aug 20:10:5219-35. doi: 10.2147/IJN.S82847. eCollection 2015. D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery Yupei Wu, Qian Chu, Songwei Tan, Xiangting Zhuang, Yuling Bao, Tingting Wu, Zhiping Zhang Abstract Paclitaxel (PTX) is one of the most effective antineoplastic drugs. Its current clinical administration Taxol(®) is formulated in Cremophor EL, which causes serious side effects. Nanoparticles (NP) with lower systemic toxicity and enhanced therapeutic efficiency may be an alternative formulation of the Cremophor EL-based vehicle for PTX delivery. In this study, novel amphipathic 4-arm-PEG-TPGS derivatives, the conjugation of D-α-tocopherol polyethylene glycol succinate (TPGS) and 4-arm-polyethylene glycol (4-arm-PEG) with different molecular weights, have been successfully synthesized and used as carriers for the delivery of PTX. These 4-arm-PEG-TPGS derivatives were able to self-assemble to form uniform NP with PTX encapsulation. Among them, 4-arm-PEG(5K)-TPGS NP exhibited the smallest particle size, highest drug-loading efficiency, negligible hemolysis rate, and high physiologic stability. Therefore, it was chosen for further in vitro and in vivo investigations. Facilitated by the effective uptake of the NP, the PTX-loaded 4-arm-PEG(5K)-TPGS NP showed greater cytotoxicity compared with free PTX against human ovarian cancer (A2780), non-small cell lung cancer (A549), and breast adenocarcinoma cancer (MCF-7) cells, as well as a higher apoptotic rate and a more significant cell cycle arrest effect at the G2/M phase in A2780 cells. More importantly, PTX-loaded 4-arm-PEG(5K)-TPGS NP resulted in a significantly improved tumor growth inhibitory effect in comparison to Taxol(®) in S180 sarcoma-bearing mice models. This study suggested that 4-arm-PEG(5K)-TPGS NP may have the potential as an anticancer drug delivery system. Keywords: 4-arm-PEG; TPGS; antitumor; nanoparticles; paclitaxel. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

We are delighted to invite you to the prestigious CPHI CHINA, where SINOPEG will be showcasing our latest innovations and products. The event will be held at the Shanghai New International Expo Center from June 19th to 21st, 2024. CPHI CHINA is a leading platform for the pharmaceutical industry, bringing together top professionals, suppliers, and manufacturers from around the world. At our booth W4G31, you will have the opportunity to witness firsthand the cutting-edge solutions and advancements that SINOPEG has to offer. Our dedicated team will be available to provide detailed information, answer any queries, and discuss potential partnerships. We cordially invite you to join us at the SINOPEG booth W4G31 at CPHI CHINA and be part of this exciting event. Your presence and engagement will contribute significantly to the success of the exhibition. We look forward to meeting you and exploring potential synergies. Please feel free to contact us if you require any further information or to schedule a meeting during the event. We can be reached at sales@sinopeg.com. Thank you for considering our invitation. We eagerly anticipate your positive response and the opportunity to connect at CPHI CHINA.

The Dragon Boat Festival, also known as Duanwu Festival, is a traditional Chinese holiday that has a history of over 2,000 years. It is celebrated on the 5th day of the 5th month of the lunar calendar, which usually falls in June on the Gregorian calendar. This festival is widely observed in many Chinese communities around the world. One of the most prominent features of the Dragon Boat Festival is the thrilling dragon boat races. Teams of rowers paddle vigorously to the beat of drums, racing their elaborately decorated boats on rivers and lakes. These races are not only a thrilling sport but also a way to commemorate the popular Chinese poet Qu Yuan. Qu Yuan was a highly respected poet and politician who lived during the Warring States period in ancient China. He was known for his love for his country and his relentless fight against corruption. When his kingdom was invaded and conquered, Qu Yuan drowned himself in the Miluo River in despair. To prevent fish from devouring his body, people raced their boats on the river, splashed water, and threw Zongzi, a traditional sticky rice dumpling, into the water as offerings. Zongzi is a special food associated with the Dragon Boat Festival. It is made by wrapping glutinous rice, with a variety of fillings such as meat, beans, or nuts, in bamboo leaves and then steaming or boiling them. These delicious treats symbolize the rice that was thrown into the river to feed the fish and divert their attention away from Qu Yuan's body. Besides dragon boat races and Zongzi, the Dragon Boat Festival also features other customs and traditions. People often hang up pouches of herbal medicines, called "zhongzi," and mugwort leaves on their doors to ward off evil spirits and diseases. Additionally, children wear colorful silk threads to protect themselves from evil spirits and bring good luck. In recent years, the Dragon Boat Festival has gained popularity beyond Chinese communities. Many countries have embraced this festive occasion and organized dragon boat races to celebrate multic.

Welcome to visit SINOPEG at booth no.911. Each year, the TIDES conference scientific agenda includes 150+ of the industry's top scientists to present the latest science and industry updates across the entire spectrum from discovery, preclinical, clinical development through CMC, Manufacturing and commercialization of therapeutics and vaccines for oligos, peptides, mRNA and genome editing products. The TIDES USA program features concurrent tracks covering the following 6 scientific themes including in-depth development strategies, trends, and technologies across the entire spectrum of oligonucleotides, peptides, mRNA, and genome editing.