We are thrilled to announce that the PharmSci 360 2024 will take place from October 20-23, 2024 in Salt Lake City, Utah. Organized by the American Association of Pharmaceutical Scientists (AAPS), which has been a key player in the pharmaceutical sciences since its inception in 1986, this event brings together over 12,000 members from academia, industry, government, and related organizations worldwide. The overarching goal of AAPS is to enhance the capabilities of pharmaceutical scientists in developing products and therapies that improve global health. PharmSci 360 aims to foster greater collaboration between small molecule and biologics scientists, offering attendees an engaging learning experience that focuses on the latest research and business objectives. The conference will highlight contemporary "hot topics" through cross-disciplinary learning experiences. Participants can look forward to presentations of cutting-edge research, validated scientific methods, and showcases of the latest technologies, services, and products. Keynote speakers will include prominent scientists from the FDA, NIH, leading pharmaceutical companies, and academia. We are also excited to share that SINOEPG will be participating in the exhibition at Booth 2620, where we will showcase our latest technological advancements. We invite everyone to stop by and connect with us! Let’s work together to advance the pharmaceutical sciences and make a positive impact on global health!

Happy Mid-Autumn Festival! As we celebrate this special time with family and friends, we want to remind our valued clients that SINOPEG will have staff regularly checking emails during the holiday. If you have any inquiries or needs, feel free to reach out to us at sales@sinopeg.com. Wishing everyone a joyous festival! #MidAutumnFestival #SINOPEG

Happy Teacher's Day! Today, we honor the incredible educators who inspire, nurture, and shape the minds of the future. Thank you for your dedication and passion in making a difference in our lives! #TeachersDay #ThankATeacher

Nat Commun.  2020 Mar 18;11(1):1435.   doi: 10.1038/s41467-020-14887-9. Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma Bin Kong, Yun Chen, Rui Liu, Xi Liu, Changyong Liu, Zengwu Shao, Liming Xiong, Xianning Liu, Wei Sun, Shengli Mi Abstract Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation.   In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold and infuse the scaffold with gelatin methacrylate (GelMA) hydrogel to obtain a 3 D fiber hydrogel construct;   the fiber spacing is adjusted to fabricate optimal construct that simulates the stromal structure with properties most similar to the native cornea.   The topological structure (3 D fiber hydrogel, 3 D GelMA hydrogel, and 2 D culture dish) and chemical factors (serum, ascorbic acid, insulin, and β-FGF) are examined to study their effects on the differentiation of limbal stromal stem cells to keratocytes or fibroblasts and the phenotype maintenance, in vitro and in vivo tissue regeneration.   The results demonstrate that fiber hydrogel and serum-free media synergize to provide an optimal environment for the maintenance of keratocyte phenotype and the regeneration of damaged corneal stroma. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

DOI https://doi.org/10.1039/C4TA05736H Citation J. Mater.    Chem.    A, 2015,3, 1158-1163 Facile functionalization of a tetrahedron-like PEG macromonomer-based fluorescent hydrogel with high strength and its heavy metal ion detection Abstract A tetrahedron-like PEG macromonomer-based fluorescent hydrogel was fabricated by a facile method.    The functional hydrogel shows comparable high strength, up to megapascals, and sensitivity to heavy metal ions, such as Cu2+, Zn2+, Pb2+, Co2+, Hg2+ and Ni2+, which allow a potentially rapid visual response, trace analysis and one-step recyclable sensing for metal ion detection. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Chemical Engineering Journal Volume 413, 1 June 2021, 127429 https://doi.org/10.1016/j.cej.2020.127429 Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing Abstract The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal4PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels. In vitro assays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities against Escherichia coli and Staphylococcus aureus due to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. The in vivo anti-infection results further demonstrated that the semi-IPN hydrogels could kill S. aureus and accelerate the healing of infected wounds. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Cite this: Langmuir 2015, 31, 51, 13834–13841 Publication Date:December 3, 2015 https://doi.org/10.1021/acs.langmuir.5b03823 Effect of Topological Structures on the Self-Assembly Behavior of Supramolecular Amphiphiles Juan Wang, Xing Wang, Fei Yang, Hong Shen, Yezi You, and Decheng Wu Abstract Three types of azobenzene-based telechelic guest polymers, PEG-azo, azo-PEG-azo, and PEG-azo4, were synthesized by a facile method.  Subsequently, a series supramolecular amphiphiles with three distinct topological structures (hemitelechelic, ditelechelic, and quadritelechelic) were constructed through coupling with host polymer β-cyclodextrin-poly(l-lactide) (β-CD-PLLA) by combined host–guest complexation.  Research on the self-assembly behavior of these amphiphiles demonstrated that the variation in self-assembly was tuned by the synergistic interaction of hydrophilicity and the curvature of the polymer chains, and very importantly, the topological structure of amphiphiles demonstrated effective control of the self-assembly behavior. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Int J Nanomedicine. 2015 Aug 20:10:5219-35. doi: 10.2147/IJN.S82847. eCollection 2015. D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery Yupei Wu, Qian Chu, Songwei Tan, Xiangting Zhuang, Yuling Bao, Tingting Wu, Zhiping Zhang Abstract Paclitaxel (PTX) is one of the most effective antineoplastic drugs. Its current clinical administration Taxol(®) is formulated in Cremophor EL, which causes serious side effects. Nanoparticles (NP) with lower systemic toxicity and enhanced therapeutic efficiency may be an alternative formulation of the Cremophor EL-based vehicle for PTX delivery. In this study, novel amphipathic 4-arm-PEG-TPGS derivatives, the conjugation of D-α-tocopherol polyethylene glycol succinate (TPGS) and 4-arm-polyethylene glycol (4-arm-PEG) with different molecular weights, have been successfully synthesized and used as carriers for the delivery of PTX. These 4-arm-PEG-TPGS derivatives were able to self-assemble to form uniform NP with PTX encapsulation. Among them, 4-arm-PEG(5K)-TPGS NP exhibited the smallest particle size, highest drug-loading efficiency, negligible hemolysis rate, and high physiologic stability. Therefore, it was chosen for further in vitro and in vivo investigations. Facilitated by the effective uptake of the NP, the PTX-loaded 4-arm-PEG(5K)-TPGS NP showed greater cytotoxicity compared with free PTX against human ovarian cancer (A2780), non-small cell lung cancer (A549), and breast adenocarcinoma cancer (MCF-7) cells, as well as a higher apoptotic rate and a more significant cell cycle arrest effect at the G2/M phase in A2780 cells. More importantly, PTX-loaded 4-arm-PEG(5K)-TPGS NP resulted in a significantly improved tumor growth inhibitory effect in comparison to Taxol(®) in S180 sarcoma-bearing mice models. This study suggested that 4-arm-PEG(5K)-TPGS NP may have the potential as an anticancer drug delivery system. Keywords: 4-arm-PEG; TPGS; antitumor; nanoparticles; paclitaxel. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com