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  • Happy Mid-Autumn Festival!
    Happy Mid-Autumn Festival! September 14,2024.
    Happy Mid-Autumn Festival! As we celebrate this special time with family and friends, we want to remind our valued clients that SINOPEG will have staff regularly checking emails during the holiday. If you have any inquiries or needs, feel free to reach out to us at sales@sinopeg.com. Wishing everyone a joyous festival! #MidAutumnFestival #SINOPEG
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  • Happy Teacher's Day!
    Happy Teacher's Day! September 10,2024.
    Happy Teacher's Day! Today, we honor the incredible educators who inspire, nurture, and shape the minds of the future. Thank you for your dedication and passion in making a difference in our lives! #TeachersDay #ThankATeacher
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  • Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma
    Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma 2024-06-05
    Nat Commun.  2020 Mar 18;11(1):1435.   doi: 10.1038/s41467-020-14887-9. Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma Bin Kong, Yun Chen, Rui Liu, Xi Liu, Changyong Liu, Zengwu Shao, Liming Xiong, Xianning Liu, Wei Sun, Shengli Mi Abstract Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation.   In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold and infuse the scaffold with gelatin methacrylate (GelMA) hydrogel to obtain a 3 D fiber hydrogel construct;   the fiber spacing is adjusted to fabricate optimal construct that simulates the stromal structure with properties most similar to the native cornea.   The topological structure (3 D fiber hydrogel, 3 D GelMA hydrogel, and 2 D culture dish) and chemical factors (serum, ascorbic acid, insulin, and β-FGF) are examined to study their effects on the differentiation of limbal stromal stem cells to keratocytes or fibroblasts and the phenotype maintenance, in vitro and in vivo tissue regeneration.   The results demonstrate that fiber hydrogel and serum-free media synergize to provide an optimal environment for the maintenance of keratocyte phenotype and the regeneration of damaged corneal stroma. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • Facile functionalization of a tetrahedron-like PEG macromonomer-based fluorescent hydrogel with high strength and its heavy metal ion detection
    Facile functionalization of a tetrahedron-like PEG macromonomer-based fluorescent hydrogel with high strength and its heavy metal ion detection 2024-05-28
    DOI https://doi.org/10.1039/C4TA05736H Citation J. Mater.    Chem.    A, 2015,3, 1158-1163 Facile functionalization of a tetrahedron-like PEG macromonomer-based fluorescent hydrogel with high strength and its heavy metal ion detection Abstract A tetrahedron-like PEG macromonomer-based fluorescent hydrogel was fabricated by a facile method.    The functional hydrogel shows comparable high strength, up to megapascals, and sensitivity to heavy metal ions, such as Cu2+, Zn2+, Pb2+, Co2+, Hg2+ and Ni2+, which allow a potentially rapid visual response, trace analysis and one-step recyclable sensing for metal ion detection. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing
    Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing 2024-05-24
    Chemical Engineering Journal Volume 413, 1 June 2021, 127429 https://doi.org/10.1016/j.cej.2020.127429 Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing Abstract The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal4PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels. In vitro assays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities against Escherichia coli and Staphylococcus aureus due to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. The in vivo anti-infection results further demonstrated that the semi-IPN hydrogels could kill S. aureus and accelerate the healing of infected wounds. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • Effect of Topological Structures on the Self-Assembly Behavior of Supramolecular Amphiphiles
    Effect of Topological Structures on the Self-Assembly Behavior of Supramolecular Amphiphiles 2024-05-21
    Cite this: Langmuir 2015, 31, 51, 13834–13841 Publication Date:December 3, 2015 https://doi.org/10.1021/acs.langmuir.5b03823 Effect of Topological Structures on the Self-Assembly Behavior of Supramolecular Amphiphiles Juan Wang, Xing Wang, Fei Yang, Hong Shen, Yezi You, and Decheng Wu Abstract Three types of azobenzene-based telechelic guest polymers, PEG-azo, azo-PEG-azo, and PEG-azo4, were synthesized by a facile method.  Subsequently, a series supramolecular amphiphiles with three distinct topological structures (hemitelechelic, ditelechelic, and quadritelechelic) were constructed through coupling with host polymer β-cyclodextrin-poly(l-lactide) (β-CD-PLLA) by combined host–guest complexation.  Research on the self-assembly behavior of these amphiphiles demonstrated that the variation in self-assembly was tuned by the synergistic interaction of hydrophilicity and the curvature of the polymer chains, and very importantly, the topological structure of amphiphiles demonstrated effective control of the self-assembly behavior. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery
    D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery 2024-05-17
    Int J Nanomedicine. 2015 Aug 20:10:5219-35. doi: 10.2147/IJN.S82847. eCollection 2015. D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery Yupei Wu, Qian Chu, Songwei Tan, Xiangting Zhuang, Yuling Bao, Tingting Wu, Zhiping Zhang Abstract Paclitaxel (PTX) is one of the most effective antineoplastic drugs. Its current clinical administration Taxol(®) is formulated in Cremophor EL, which causes serious side effects. Nanoparticles (NP) with lower systemic toxicity and enhanced therapeutic efficiency may be an alternative formulation of the Cremophor EL-based vehicle for PTX delivery. In this study, novel amphipathic 4-arm-PEG-TPGS derivatives, the conjugation of D-α-tocopherol polyethylene glycol succinate (TPGS) and 4-arm-polyethylene glycol (4-arm-PEG) with different molecular weights, have been successfully synthesized and used as carriers for the delivery of PTX. These 4-arm-PEG-TPGS derivatives were able to self-assemble to form uniform NP with PTX encapsulation. Among them, 4-arm-PEG(5K)-TPGS NP exhibited the smallest particle size, highest drug-loading efficiency, negligible hemolysis rate, and high physiologic stability. Therefore, it was chosen for further in vitro and in vivo investigations. Facilitated by the effective uptake of the NP, the PTX-loaded 4-arm-PEG(5K)-TPGS NP showed greater cytotoxicity compared with free PTX against human ovarian cancer (A2780), non-small cell lung cancer (A549), and breast adenocarcinoma cancer (MCF-7) cells, as well as a higher apoptotic rate and a more significant cell cycle arrest effect at the G2/M phase in A2780 cells. More importantly, PTX-loaded 4-arm-PEG(5K)-TPGS NP resulted in a significantly improved tumor growth inhibitory effect in comparison to Taxol(®) in S180 sarcoma-bearing mice models. This study suggested that 4-arm-PEG(5K)-TPGS NP may have the potential as an anticancer drug delivery system. Keywords: 4-arm-PEG; TPGS; antitumor; nanoparticles; paclitaxel. Related products Abbreviation: 4-arm-PEG For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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  • SINOEPG's invitation | CPHI China
    SINOEPG's invitation | CPHI China June 17,2024.
    We are delighted to invite you to the prestigious CPHI CHINA, where SINOPEG will be showcasing our latest innovations and products. The event will be held at the Shanghai New International Expo Center from June 19th to 21st, 2024. CPHI CHINA is a leading platform for the pharmaceutical industry, bringing together top professionals, suppliers, and manufacturers from around the world. At our booth W4G31, you will have the opportunity to witness firsthand the cutting-edge solutions and advancements that SINOPEG has to offer. Our dedicated team will be available to provide detailed information, answer any queries, and discuss potential partnerships. We cordially invite you to join us at the SINOPEG booth W4G31 at CPHI CHINA and be part of this exciting event. Your presence and engagement will contribute significantly to the success of the exhibition. We look forward to meeting you and exploring potential synergies. Please feel free to contact us if you require any further information or to schedule a meeting during the event. We can be reached at sales@sinopeg.com. Thank you for considering our invitation. We eagerly anticipate your positive response and the opportunity to connect at CPHI CHINA.
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