Happy Spring Festival! The long-awaited Spring Festival holiday is here! I can't wait to share some exciting news and the festive atmosphere surrounding the Chinese New Year break. Are you ready? Let's embrace this traditional festival together!  Firstly, the Spring Festival is one of the most important traditional holidays in China and is eagerly anticipated by people nationwide. The dates vary each year, typically starting on the first day of the lunar new year and lasting for fifteen days. We have plenty of time to enjoy and celebrate this special occasion. During the Spring Festival holiday, people usually return home to reunite with their families and enjoy joyful moments together. Regardless of their location, loved ones strive to gather at home on this day. That's why train stations and airports throughout the country are exceptionally busy during the Spring Festival travel rush, as thousands of people aim to be home for the Lunar New Year celebration. This reunion moment holds great significance for Chinese people, so they remain positive and optimistic amidst crowded roads and heavy luggage, embracing the spirit of the Spring Festival travel rush. Throughout the Spring Festival period, households engage in a series of celebration activities. First and foremost, people put up spring couplets and fu characters on their doors to pray for good fortune and happiness in the coming year. Traditional decorations like lanterns, papercuttings, and window decorations adorn homes, creating a festive ambiance. And of course, there are red envelopes, which are the favorite part for children! Elders give red envelopes containing lucky money to children, symbolizing good luck and prosperity. Additionally, there are sumptuous reunion dinners, where traditional delicacies such as rice dumplings and sticky rice cakes are enjoyed, representing reunion and well wishes. Apart from family gatherings, people participate in various traditional and festive activities. Lion dances, dragon dances, and lantern exhibitions take place on the streets, spreading joyous vibes throughout the cities. Furthermore, temple fairs and flower markets are popular destinations during the Spring Festival, offering a chance to savor delicious food, purchase New Year gifts, and witness traditional performances. While the Spring Festival remains rooted in tradition, it continues to evolve. The advancement of modern technology allows people to send wishes to family and friends via the internet, enabling them to experience the reunion atmosphere regardless of their geographic location. Additionally, some people choose to travel and explore new destinations to unwind during the festivities. The Spring Festival holiday is a time of excitement and celebration. Whether it's reuniting with family or participating in festive activities, this holiday creates wonderful memories and joyous moments for everyone. Let's cherish this traditional festival together and wish everyone a happy new y...

Mol Pharm. 2014 Oct 6;11(10):3656-70.  doi: 10.1021/mp500399j.  Epub 2014 Sep 24. Novel free-paclitaxel-loaded redox-responsive nanoparticles based on a disulfide-linked poly(ethylene glycol)-drug conjugate for intracellular drug delivery: synthesis, characterization, and antitumor activity in vitro and in vivo Xingxing Chuan 1, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang, Qiang Zhang Abstract To address the obstacles facing cancer chemotherapeutics, including toxicity, side effects, water insolubility, and lack of tumor selectivity, a novel stimuli-responsive drug-delivery system was developed based on paclitaxel-loaded poly(ethylene glycol)-disulfide-paclitaxel conjugate nanoparticles (PEG-SS-PTX/PTX NPs).  The formulation emphasizes several benefits, including polymer-drug conjugates/prodrugs, self-assembled NPs, high drug content, redox responsiveness, and programmed drug release.  The PTX-loaded, self-assembled NPs, with a uniform size of 103 nm, characterized by DLS, TEM, XRD, DSC, and (1)H NMR, exhibited excellent drug-loading capacity (15.7%) and entrapment efficiency (93.3%).  PEG-SS-PTX/PTX NPs were relatively stable under normal conditions but disassembled quickly under reductive conditions, as indicated by their triggered-aggregation phenomena and drug-release profile in the presence of dithiothreitol (DTT), a reducing agent.  Additionally, by taking advantage of the difference in the drug-release rates between physically loaded and chemically conjugated drugs, a programmed drug-release phenomenon was observed, which was attributed to a higher concentration and longer action time of the drugs.  The influence of PEG-SS-PTX/PTX NPs on in vitro cytotoxicity, cell cycle progression, and cellular apoptosis was determined in the MCF-7 cell line, and the NPs demonstrated a superior anti-proliferative activity associated with PTX-induced cell cycle arrest in G2/M phase and apoptosis compared to their nonresponsive counterparts.  Moreover, the redox-responsive NPs were more efficacious than both free PTX and the non-redox-responsive formulation at equivalent doses of PTX in a breast cancer xenograft mouse model.  This redox-responsive PTX drug delivery system is promising and can be explored for use in effective intracellular drug delivery. Keywords: paclitaxel;  polymeric nanoparticles;  polymer−drug conjugates/prodrugs;  programmed drug release;  redox-response. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol Abbreviation: mPEG-PA Name: Methoxypoly(ethylene glycol) propionic acid For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2015 Jul 8;7(26):14369-75.    doi: 10.1021/acsami.5b03106.    Epub 2015 Jun 24. Optimization of Surface Coating on Small Pd Nanosheets for in Vivo near-Infrared Photothermal Therapy of Tumor Saige Shi 1 2, Yizhuan Huang 1, Xiaolan Chen 1, Jian Weng 2, Nanfeng Zheng 1 Abstract Palladium nanosheets with strong near-infrared absorption have been recently demonstrated as promising photothermal agents for photothermal therapy (PTT) of cancers.    However, systematic assessments of their potential risks and impacts to biological systems have not been fully explored yet.    In this work, we carefully investigate how surface coatings affect the in vivo behaviors of small Pd nanosheets (Pd NSs).    Several biocompatible molecules such as carboxymethyl chitosan (CMC), PEG-NH2, PEG-SH, and dihydrolipoic acid-zwitterion (DHLA-ZW) were used to coat Pd NSs.    The blood circulation half-lives, biodistribution, potential toxicity, clearance, and photothermal effect of different surface-coated Pd NSs in mice after intravenous injection were compared.    PEG-SH-coated Pd NSs (Pd-HS-PEG) were found to have ultralong blood circulation half-life and show high uptake in the tumor.    We then carry out the in vivo photothermal therapeutic studies on the Pd-HS-PEG conjugate and revealed its outstanding efficacy in in vivo photothermal therapy of cancers.    Our results highlight the importance of surface coatings to the in vivo behaviors of nanomaterials and can provide guidelines to the future design of Pd NSs bioconjugates for other in vivo applications. Keywords: in vivo behaviors;    nanosheet;    palladium;    photothermal therapy;    surface coating. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol Abbreviation: mPEG-NH2 Name: Methoxypoly(ethylene glycol) amine For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Biomaterials. 2017 Oct:141:116-124.  doi: 10.1016/j.biomaterials.2017.06.030.  Epub 2017 Jun 27. Autophagy inhibition enabled efficient photothermal therapy at a mild temperature Zhengjie Zhou 1, Yang Yan 1, Kewen Hu 1, Yuan Zou 2, Yiwen Li 2, Rui Ma 1, Qiang Zhang 3, Yiyun Cheng 4 Abstract The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal therapy commonly results in incomplete tumor eradication and serious damage of health tissue.  Here, we found autophagy was activated in cancer cells underwent photothermal therapy and the inhibition of autophagy significantly enhanced the efficacy of photothermal killing of cancer cells.  A formulation of chloroquine-loaded polydopamine nanoparticles was developed for sensitized photothermal cancer therapy, and the in vitro and in vivo study demonstrated that inhibition of autophagy remarkably augmented the efficacy of photothermal therapy, leading to efficient tumor suppression at a mild temperature.  The regulation of autophagy provides a new route to increase the efficacy of photothermal cancer therapy. Keywords: Autophagy;  Chloroquine;  Photothermal therapy;  Polydopamine nanoparticles;  Sensitization. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol Abbreviation: H2N-PEG-SH Name: α-Amino-ω-mercapto poly(ethylene glycol) For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2014 Nov 26;6(22):19544-51.  doi: 10.1021/am505649q.  Epub 2014 Nov 14. Supramolecular hybrid hydrogel based on host-guest interaction and its application in drug delivery Jing Yu 1, Wei Ha, Jian-nan Sun, Yan-ping Shi Abstract In this work, we developed a simple, novel method for constructing gold nanocomposite supramolecular hybrid hydrogels for drug delivery, in which gold nanocrystals were utilized as building blocks.  First, methoxypoly(ethylene glycol) thiol (mPEG-SH, molecular weight (MW)=5 K) capped gold nanocrystals (nanospheres and nanorods) were prepared via a facile one-step ligand-exchange procedure.  Then, the homogeneous supramolecular hybrid hydrogels were formed, after adding α-cyclodextrin (α-CD) into PEG-modified gold nanocrystal solutions, due to the host-guest inclusion.  Both gold nanoparticles and inclusion complexes formed between α-CD and PEG chain provided the supra-cross-links, which are beneficial to the gelation formation.  The resulting hybrid hydrogels were fully characterized by a combination of techniques including X-ray diffraction, rheology studies, and scanning electron microscopy.  Meanwhile, the hybrid hydrogel systems demonstrated unique reversible gel-sol transition properties at a certain temperature caused by the temperature-responsive reversible supramolecular assembly.  The drug delivery applications of such hybrid hydrogels were further investigated in which doxorubicin was selected as a model drug for in vitro release, cytotoxicity, and intracellular release studies.  We believe that the development of such hybrid hydrogels will provide new and therapeutically useful means for medical applications. Keywords: drug delivery;  gold nanoparticles;  host−guest inclusion;  supramolecular hybrid hydrogel. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Biomaterials. 2014 Aug;35(25):7058-67.    doi: 10.1016/j.biomaterials.2014.04.105.    Epub 2014 May 20. Stability enhanced polyelectrolyte-coated gold nanorod-photosensitizer complexes for high/low power density photodynamic therapy Zhenzhi Shi 1, Wenzhi Ren 1, An Gong 1, Xinmei Zhao 1, Yuehong Zou 1, Eric Michael Bratsolias Brown 2, Xiaoyuan Chen 3, Aiguo Wu 4 Abstract Photodynamic therapy (PDT) is a promising treatment modality for cancer and other malignant diseases, however safety and efficacy improvements are required before it reaches its full potential and wider clinical use.    Herein, we investigated a highly efficient and safe photodynamic therapy procedure by developing a high/low power density photodynamic therapy mode (high/low PDT mode) using methoxypoly(ethylene glycol) thiol (mPEG-SH) modified gold nanorod (GNR)-AlPcS4 photosensitizer complexes.    mPEG-SH conjugated to the surface of simple polyelectrolyte-coated GNRs was verified using Fourier transform infrared spectroscopy;    this improved stability, reduced cytotoxicity, and increased the encapsulation and loading efficiency of the nanoparticle dispersions.    The GNR-photosensitizer complexes were exposed to the high/low PDT mode (high light dose = 80 mW/cm(2) for 0.5 min;    low light dose = 25 mW/cm(2) for 1.5 min), and a high PDT efficacy leads to approximately 90% tumor cell killing.    Due to synergistic plasmonic photothermal properties of the complexes, the high/low PDT mode demonstrated improved efficacy over using single wavelength continuous laser irradiation.    Additionally, no significant loss in viability was observed in cells exposed to free AlPcS4 photosensitizer under the same irradiation conditions.    Consequently, free AlPcS4 released from GNRs prior to cellular entry did not contribute to cytotoxicity of normal cells or impose limitations on the use of the high power density laser.    This high/low PDT mode may effectively lead to a safer and more efficient photodynamic therapy for superficial tumors. Keywords: AlPcS4 photosensitizer;    Gold nanorods;    High/low power density;    Near-infrared;    Photodynamic therapy (PDT);    Synergistic therapy. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Biomaterials. 2018 Mar:158:23-33.   doi: 10.1016/j.biomaterials.2017.12.009.   Epub 2017 Dec 13. Rattle-type Au@Cu2-xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy Yu Cao 1, Shuzhou Li 2, Chao Chen 2, Dongdong Wang 1, Tingting Wu 1, Haifeng Dong 3, Xueji Zhang 4 Abstract The coupling of the localized surface plasma resonance (LSPR) between noble metals of Au, Ag and Cu and semiconductors of Cu2-xE (E = S, Se, Te) opens new regime to design photothermal (PT) agents with enhanced PT conversion efficiency.   However, it is rarely explored on fabricating of engineered dual plasmonic hybrid nanosystem for combinatory therapeutic-diagnostic applications.   Herein, rattle-type Au@Cu2-xS hollow mesoporous nanoparitcles with advanced PT conversion efficiency are designed for cellular vehicles and chemo-photothermal synergistic therapy platform.   The LSPR coupling between the Au core and Cu2-xS shell are investigated experimentally and theoretically to generate a PT conversion efficiency high to 35.2% and enhanced by 11.3% than that of Cu2-xS.   By conjugating microRNA (miRNA) gene probe on the surface, it can realize the intracellular oncogenic miRNA detection.   After loading of anticancer drug doxorubicin into the cavity of the Au@Cu2-xS, the antitumor therapy efficacy is greatly enhanced in vitro and in vivo due to the NIR photoactivation chemo- and photothermal synergistic therapy.   The rattle-type metal-semiconductor hollow mesoporous nanostructure with efficient LSPR coupling and high cargo loading capability will be beneficial to future design of LSPR-based photothermal agents for a broad range of biomedical application. Keywords: Chemo-photothermal therapy;   Localized surface plasma resonance coupling;   MicroRNA detection;   Rattle-type Au@Cu(2−x)S;   Theranostic platform. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Chem Sci. 2018 Apr 12;9(18):4268-4274.  doi: 10.1039/c8sc00104a.  eCollection 2018 May 14. Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy Mei Chen 1 2, Zhide Guo 3, Qinghua Chen 4, Jingping Wei 1, Jingchao Li 1, Changrong Shi 3, Duo Xu 3, Dawang Zhou 4, Xianzhong Zhang 3, Nanfeng Zheng 1 Abstract Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy.  However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges.  Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of 131I and 125I on their surfaces (denoted as 131I-Pd-PEG or 125I-Pd-PEG).  Systematic studies reveal that the labeling efficiency is higher than 98% and the adsorption of radioiodine is more stable in an acidic environment.  In vivo studies further validate the pH-dependent behavior of this platform and the enhanced retention of radioisotopes in tumors due to the acidic microenvironment.  Single photon emission computed tomography (SPECT) images with zero background were successfully achieved in a subcutaneous 4T1 tumor model, an orthotopic LM3 tumor model, and even in a Mst1/2 double-knockout hepatoma model.  Moreover, the application of radiolabeled Pd nanosheets for photoacoustic (PA) imaging, and combined photothermal and radiotherapy was also explored.  Therefore, this study provides a simple and efficient strategy to solve the critical high background issue of radiolabeled nanoparticles and shows enormous potential for clinical applications. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com