ACS Appl Bio Mater. 2019 Jun 17;2(6):2444-2452. doi: 10.1021/acsabm.9b00156. Epub 2019 May 15. Bone Marrow Mesenchymal Stem Cells Encapsulated in a Hydrogel System via Bioorthogonal Chemistry for Liver Regeneration Yajie Zhang, Yue Zan, Hong Chen, Zhili Wang, Tianyu Ni, Min Liu, Renjun Pei Abstract Liver tissue engineering is going to be an effective treatment for end-stage liver disease. In this work, we distributed bone marrow mesenchymal stem cells (BMSCs) into a fast-forming hydrogel system to develop a liver-mimicking construct for liver regeneration. The advantage of this hydrogel system was that this BMSC-encapsulating hydrogel could be formed via a bioorthogonal reaction between 2-cyanobenzothiazole and cysteine within several seconds. Thereafter, we explored the morphology, biocompatibility, and expressions of hepatic differentiation markers of this hydrogel system. These results illustrated that this system could provide a suitable niche for BMSC proliferation and differentiation, which could aid in future biomedical research of liver regeneration. Keywords: BMSC-encapsulating; bioorthogonal reaction; fast-forming hydrogel; liver regeneration; tissue engineering. Related products Abbreviation: 4-arm PEG-NH2 Name: 4-arm Poly(ethylene glycol) amine Abbreviation: 4-arm PEG-CM Name: 4-arm Poly(ethylene glycol) carboxylic acid For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com
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