Chem Sci. 2018 Apr 12;9(18):4268-4274.  doi: 10.1039/c8sc00104a.  eCollection 2018 May 14. Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy Mei Chen 1 2, Zhide Guo 3, Qinghua Chen 4, Jingping Wei 1, Jingchao Li 1, Changrong Shi 3, Duo Xu 3, Dawang Zhou 4, Xianzhong Zhang 3, Nanfeng Zheng 1 Abstract Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy.  However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges.  Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of 131I and 125I on their surfaces (denoted as 131I-Pd-PEG or 125I-Pd-PEG).  Systematic studies reveal that the labeling efficiency is higher than 98% and the adsorption of radioiodine is more stable in an acidic environment.  In vivo studies further validate the pH-dependent behavior of this platform and the enhanced retention of radioisotopes in tumors due to the acidic microenvironment.  Single photon emission computed tomography (SPECT) images with zero background were successfully achieved in a subcutaneous 4T1 tumor model, an orthotopic LM3 tumor model, and even in a Mst1/2 double-knockout hepatoma model.  Moreover, the application of radiolabeled Pd nanosheets for photoacoustic (PA) imaging, and combined photothermal and radiotherapy was also explored.  Therefore, this study provides a simple and efficient strategy to solve the critical high background issue of radiolabeled nanoparticles and shows enormous potential for clinical applications. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Int J Pharm. 2016 Jan 30;497(1-2):210-21. doi: 10.1016/j.ijpharm.2015.11.032. Epub 2015 Dec 1. Nanocomposite hydrogel incorporating gold nanorods and paclitaxel-loaded chitosan micelles for combination photothermal-chemotherapy Nan Zhang 1, Xuefan Xu 1, Xue Zhang 1, Ding Qu 1, Lingjing Xue 2, Ran Mo 1, Can Zhang 3 Abstract Development of combination photothermal-chemotherapy platform is of great interest for enhancing antitumor efficacy and inhibiting tumor recurrence, which supports selective and dose-controlled delivery of heat and anticancer drugs to tumor. Here, an injectable nanocomposite hydrogel incorporating PEGylated gold nanorods (GNRs) and paclitaxel-loaded chitosan polymeric micelles (PTX-M) is developed in pursuit of improved local tumor control. After intratumoral injection, both GNRs and PTX-M can be simultaneously delivered and immobilized in the tumor tissue by the thermo-sensitive hydrogel matrix. Exposure to the laser irradiation induces the GNR-mediated photothermal damage confined to the tumor with sparing the surrounding normal tissue. Synergistically, the co-delivered PTX-M shows prolonged tumor retention with the sustained release of anticancer drug to efficiently kill the residual tumor cells that evade the photothermal ablation due to the heterogeneous heating in the tumor region. This combination photothermal-chemotherapy presents superior effects on suppressing the tumor recurrence and prolonging the survival in the Heps-bearing mice, compared to the photothermal therapy alone. Keywords: Chemotherapy; Chitosan micelles; Combination therapy; Gold nanorod; Photothermal therapy. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2017 Sep 13;9(36):31153-31160.   doi: 10.1021/acsami.7b09529.   Epub 2017 Aug 30. Mixed Self-Assembly of Polyethylene Glycol and Aptamer on Polydopamine Surface for Highly Sensitive and Low-Fouling Detection of Adenosine Triphosphate in Complex Media Guixiang Wang 1 2, Qingjun Xu 1, Lei Liu 1, Xiaoli Su 1, Jiehua Lin 1, Guiyun Xu 1, Xiliang Luo 1 Abstract Detection of disease biomarkers within complex biological media is a substantial outstanding challenge because of severe biofouling and nonspecific adsorptions.   Herein, a reliable strategy for sensitive and low-fouling detection of a biomarker, adenosine triphosphate (ATP) in biological samples was developed through the formation of a mixed self-assembled sensing interface, which was constructed by simultaneously self-assembling polyethylene glycol (PEG) and ATP aptamer onto the self-polymerized polydopamine-modified electrode surface.   The developed aptasensor exhibited high selectivity and sensitivity toward the detection of ATP, and the linear range was 0.1-1000 pM, with a detection limit down to 0.1 pM.   Moreover, owing to the presence of PEG within the sensing interface, the aptasensor was capable of sensing ATP in complex biological media such as human plasma with significantly reduced nonspecific adsorption effect.   Assaying ATP in real biological samples including breast cancer cell lysates further proved the feasibility of this biosensor for practical application. Keywords: adenosine triphosphate;   antifouling;   aptasensor;   cancer cell lysates;   polydopamine;   polyethylene glycol. Related products Abbreviation: mPEG-SH Name: Methoxypoly(ethylene glycol) thiol For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Happy New Year! Wishing you all a year filled with joy, success, and endless possibilities. May this new year bring you happiness and fulfillment in everything you do. Let's embrace new beginnings and make the most of every moment. Cheers to a fantastic year ahead! #NewYear #2024

Sci Rep. 2017 Mar 31:7:45633.  doi: 10.1038/srep45633. Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers Yulei Chang 1, Xiaodan Li 1 2, Li Zhang 1 2, Lu Xia 1, Xiaomin Liu 1, Cuixia Li 1, Youlin Zhang 1, Langping Tu 1 3, Bin Xue 1 3, Huiying Zhao 2, Hong Zhang 3, Xianggui Kong 1 Abstract Recent advances in upconversion nanophotosensitizers (UCNPs-PS) excited by near-infrared (NIR) light have led to substantial progress in improving photodynamic therapy (PDT) of cancer.  For a successful PDT, subcellular organelles are promising therapeutic targets for reaching a satisfactory efficacy.  It is of vital importance for these nanophotosensitizers to reach specifically the organelles and to perform PDT with precise time control.  To do so, we have in this work traced the dynamic subcellular distribution, especially in organelles such as lysosomes and mitochondria, of the poly(allylamine)-modified and dual-loaded nanophotosensitizers.  The apoptosis of the cancer cells induced by PDT with the dependence of the distribution status of the nanophotosensitizers in organelles was obtained, which has provided an in-depth picture of intracellular trafficking of organelle-targeted nanophotosensitizers.  Our results shall facilitate the improvement of nanotechnology assisted photodynamic therapy of cancers. Related products Abbreviation: mPEG-SC Name: Methoxypoly(ethylene glycol) succinimidyl carbonate For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2018 Feb 7;10(5):4359-4368.  doi: 10.1021/acsami.7b12005.  Epub 2018 Jan 23. Near-Infrared Fluorescent Nanoprobes for Revealing the Role of Dopamine in Drug Addiction Peijian Feng 1, Yulei Chen 1, Lei Zhang 2, Cheng-Gen Qian 1, Xuanzhong Xiao 1, Xu Han 1, Qun-Dong Shen 1 Abstract Brain imaging techniques enable visualizing the activity of central nervous system without invasive neurosurgery.  Dopamine is an important neurotransmitter.  Its fluctuation in brain leads to a wide range of diseases and disorders, like drug addiction, depression, and Parkinson's disease.  We designed near-infrared fluorescence dopamine-responsive nanoprobes (DRNs) for brain activity imaging during drug abuse and addiction process.  On the basis of light-induced electron transfer between DRNs and dopamine and molecular wire effect of the DRNs, we can track the dynamical change of the neurotransmitter level in the physiological environment and the releasing of the neurotransmitter in living dopaminergic neurons in response to nicotine stimulation.  The functional near-infrared fluorescence imaging can dynamically track the dopamine level in the mice midbrain under normal or drug-activated condition and evaluate the long-term effect of addictive substances to the brain.  This strategy has the potential for studying neural activity under physiological condition. Keywords: brain activity;  dopamine-responsive;  drug addiction;  functional neuroimaging;  near-infrared fluorescence. Related products Abbreviation: mPEG-SC Name: Methoxypoly(ethylene glycol) succinimidyl carbonate For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

ACS Appl Mater Interfaces. 2015 Aug 26;7(33):18581-9. doi: 10.1021/acsami.5b04987. Epub 2015 Aug 12. Conjugated Polymer Nanoparticles for Fluorescence Imaging and Sensing of Neurotransmitter Dopamine in Living Cells and the Brains of Zebrafish Larvae Cheng-Gen Qian 1, Sha Zhu 1, Pei-Jian Feng 1, Yu-Lei Chen 1, Ji-Cheng Yu 1, Xin Tang 1, Yun Liu 1, Qun-Dong Shen 1 Abstract Nanoscale materials are now attracting a great deal of attention for biomedical applications. Conjugated polymer nanoparticles have remarkable photophysical properties that make them highly advantageous for biological fluorescence imaging. We report on conjugated polymer nanoparticles with phenylboronic acid tags on the surface for fluorescence detection of neurotransmitter dopamine in both living PC12 cells and brain of zebrafish larvae. The selective enrichment of dopamine and fluorescence signal amplification characteristics of the nanoparticles show rapid and high-sensitive probing such neurotransmitter with the detection limit of 38.8 nM, and minimum interference from other endogenous molecules. It demonstrates the potential of nanomaterials as a multifunctional nanoplatform for targeting, diagnosis, and therapy of dopamine-relative disease. Keywords: bioimaging; conjugated polymers; dopamine; fluorescence sensing; nanoparticles. Related products Abbreviation: mPEG-SC Name: Methoxypoly(ethylene glycol) succinimidyl carbonate For more product information, please contact us at: US Tel: 1-844-782-5734 US Tel: 1-844-QUAL-PEG CHN Tel: 400-918-9898 Email: sales@sinopeg.com

Acromegaly is a rare debilitating endocrine disease characterised by hypersecretion of growth hormone (GH). It is generally accepted that the clinical manifestations of acromegaly are mediated through elevations in serum IGF-I concentrations. Somavert is indicated for the treatment of patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalize IGF-I concentrations or was not tolerated. Pegvisomant, the active substance in Somavert, is a 40-50 kDa molecular variant of the human growth hormone (hGH) consisting of recombinant protein component and polyethylene glycol (PEG). The protein molecule (B2036) is modified by covalent addition of  polyethylene glycol (PEG) molecules resulting in a pegylated protein (B2036-PEG) with 4 and 5 PEG groups per B2036-PEG molecule. The purpose of direct pegylation of the protein was used to prolong half-life of B2036 and to reduce a potential immunogenicity. B2036-PEG showed decreased binding at the site 2 of the HGHR compared with B2036. Despite the reduced affinity for the receptor, work on the protein had shown increased potency of the pegylated form due to the prolonged circulating half-life . The pharmacodynamic studies presented showed that pegvisomant is a potent competitive and specific antagonist of hGH binding in vitro and in vivo. Reference: https://www.ema.europa.eu/en/documents/scientific-discussion/somavert-epar-scientific-discussion_en.pdf Linear Monofunctional PEGs Linear Bifunctional PEGs Linear Heterofunctional PEGs 2-arm (LYS) Polyethylene Glycol 2-arm (PTO2) Polyethylene Glycol 2-arm (GLY) Polyethylene Glycol 2-arm (Fluorene) Polyethylene glycol Y type (Y1PTO2) Polyethylene Glycol 3-arm Polyethylene Glycol 4-arm Polyethylene Glycol 6-arm (DP) Polyethylene Glycol 8-arm (TP) Polyethylene Glycol 8-arm (HG) Polyethylene Glycol 8-arm (SUC) Polyethylene Glycol